… not sufficient to maintain virus-specific CD8 T cells over time during … viral peptide is required
for virus-specific CD8 T cell persistence during chronic infection. Moreover, this viral antigen…

… A more detailed understanding of how viral antigens are naturally presented to TCD8+ is
essential to the rational design of TCD8+ vaccines. Although in vitro experiments provide …

… This 10 4 - to 10 5 -fold expansion indicates that, at the peak of proliferation, antigen-specific
CD8 T cells can divide approximately every 6 to 8 h (85). Along with this dramatic …

… Once this interaction was disrupted by the anti-PD-L1 blocking antibody, the ‘brake’ was
released and the exhausted CD8 T cells could proliferate in response to viral antigen. …

… with lymphocytic choriomeningitis virus. We found that during a chronic infection virus-specific
CD8 T cells failed to acquire the cardinal memory T cell property of long-term antigen-…

… responding T cells has not been defined. To address this issue we used tetramers of MHC
class I molecules containing viral peptides to directly visualize antigen-specific CD8 T cells …

… cells, which sustain acute and chronic liver damage. Using virus-specific CD8 T cells and
human hepatocytes, we analyzed the modulation of virus-specific CD8 T-cell function …

… virus-specific CD8 T cells and antibodies may provide optimal protective immunity. Herein,
we review the current literature on CD8 T cell responses induced by respiratory virus … viruses, …

… To see if we could emulate the bystander proliferation of non–virus-specific CD8 + T cells
during infection, we transferred 10 7 purified OT-1 CD8 + T cells into age- and sex-matched …

… CD8 + T cells play a critical role in controlling viral as well … there is a marked expansion
of CD8 + T cells. In humans this is … In mice, CD8 expansion occurs during vaccinia virus, …