[HTML][HTML] Four-tiered π interaction at the dimeric interface of HIV-1 integrase critical for DNA integration and viral infectivity
… Whereas viruses with an intact π electron orbital interaction at the … dimeric interface
replicated comparable to wild type, viruses containing an abolished π interaction were non-infectious…
replicated comparable to wild type, viruses containing an abolished π interaction were non-infectious…
Dimerization of matrix protein is required for budding of respiratory syncytial virus
A Förster, GN Maertens, PJ Farrell, M Bajorek - Journal of virology, 2015 - Am Soc Microbiol
… that dimerization interface mutants of M fail to assemble into viral filaments on the plasma
membrane. Additionally, budding and release of virus… and production of infectious virus, but the …
membrane. Additionally, budding and release of virus… and production of infectious virus, but the …
HIV-1 protease dimer interface mutations that compensate for viral reverse transcriptase instability in infectious virions
I Olivares, A Mulky, PI Boross, J Tözsér… - Journal of molecular …, 2007 - Elsevier
… in viral infectivity (Figure 3(a)). The wild-type was about 42 times more infectious than the …
(F130W), and >2900 times more infectious than the virus collected from cell supernatants of …
(F130W), and >2900 times more infectious than the virus collected from cell supernatants of …
Dimer interface organization is a main determinant of intermonomeric interactions and correlates with evolutionary relationships of retroviral and retroviral-like Ddi1 …
… of dimer interfaces can be differentiated, and we used the following classification of the dimer
interfaces. … hyperplasia virus type 1 (WEHV-1) PR, homodimeric equine infectious anemia …
interfaces. … hyperplasia virus type 1 (WEHV-1) PR, homodimeric equine infectious anemia …
A symmetric region of the HIV-1 integrase dimerization interface is essential for viral replication
E Serrao, W Thys, J Demeulemeester, LQ Al-Mawsawi… - 2012 - journals.plos.org
… made at the dimeric interface abolished in … viral clone and showed that, although exogenous
RT activity mostly resembled WT levels, dimeric interface mutant viruses were non-infectious…
RT activity mostly resembled WT levels, dimeric interface mutant viruses were non-infectious…
Dimerization of hepatitis E virus capsid protein E2s domain is essential for virus–host interaction
S Li, X Tang, J Seetharaman, C Yang, Y Gu… - PLoS …, 2009 - journals.plos.org
… site-directed mutagenesis targeting the dimer interface, as well as the … of viral infection.
Further, our studies suggest that the … Dimeric interface residues from both subunits are shown in …
Further, our studies suggest that the … Dimeric interface residues from both subunits are shown in …
The capsid protein of human immunodeficiency virus: intersubunit interactions during virus assembly
MG Mateu - The FEBS journal, 2009 - Wiley Online Library
… The structural description of the dimerization interface in the isolated CTD dimer is fully …
resulted in a loss of viral infectivity. Thus, the mature HIV-1 capsid/viral core does appear to have …
resulted in a loss of viral infectivity. Thus, the mature HIV-1 capsid/viral core does appear to have …
Synthetic “interface” peptides alter dimeric assembly of the HIV 1 and 2 proteases
LM Babé, J Rosé, CS Craik - Protein Science, 1992 - Wiley Online Library
… Peptides mimicking one 6-strand (residues 95-99), or two &strands (residues 1-5 plus 95-99
or 95-99 plus 95-99) from the human immunodeficiency virus 1 (HIVl) interface were shown …
or 95-99 plus 95-99) from the human immunodeficiency virus 1 (HIVl) interface were shown …
Key dimer interface residues impact the catalytic activity of 3CLpro, the main protease of SARS-CoV-2
JC Ferreira, S Fadl, WM Rabeh - Journal of Biological Chemistry, 2022 - ASBMB
… viral proteins essential for the maturation and infectivity of severe acute respiratory syndrome
coronavirus 2, the virus … active as a dimer, making the dimerization interface a target for …
coronavirus 2, the virus … active as a dimer, making the dimerization interface a target for …
Covalently linked dengue virus envelope glycoprotein dimers reduce exposure of the immunodominant fusion loop epitope
A Rouvinski, W Dejnirattisai, P Guardado-Calvo… - Nature …, 2017 - nature.com
… a strong infection enhancing … the dimer interface located such that their replacement by
cysteine could potentially lead to formation of inter-subunit disulfide bonds and improve sE-dimer …
cysteine could potentially lead to formation of inter-subunit disulfide bonds and improve sE-dimer …
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