[HTML][HTML] Ceramide and related molecules in viral infections

N Beckmann, KA Becker - International Journal of Molecular Sciences, 2021 - mdpi.com
Ceramide can be key for the formation of viral replication sites. Sphingomyelinases often …
ceramide synthesis enhances IAV replication [121], and exogenous ceramide reduces viral

Ceramide Suppresses Influenza A Virus Replication In Vitro

N Soudani, R Hage-Sleiman, W Karam… - Journal of …, 2019 - Am Soc Microbiol
… role of ceramide during influenza A virus infection. We demonstrate that ceramide produced
through … This increase in total viral RNA upon inhibition of ceramide synthesis resulted in an …

Involvement of ceramide in the propagation of Japanese encephalitis virus

H Tani, M Shiokawa, Y Kaname, H Kambara… - Journal of …, 2010 - Am Soc Microbiol
… SMase induces production of ceramide, we next examined the effect of ceramide on the
infectivity of the viruses. Treatment of the pseudotype particles with C 6 -ceramide inhibited the …

Human T-cell lymphotropic virus type I-transformed T-cells have a partial defect in ceramide synthesis in response to N-(4-hydroxyphenyl)retinamide

N Darwiche, G Abou-Lteif, T Najdi… - Biochemical …, 2005 - portlandpress.com
… confirming their defect in de novo ceramide synthesis. Owing to its multipotent … ceramide
synthesis. Tax-transfected Molt-4 and HELA cells were less sensitive to HPR and C 6 -ceramide

A ceramide analogue stimulates dendritic cells to promote T cell responses upon virus infections

CJ Pritzl, YJ Seo, C Xia, M Vijayan… - The Journal of …, 2015 - journals.aai.org
… that a synthetic ceramide analog (C8) stimulates DCs to increase the expansion of virus-specific
T cells upon virus infection. Exogenously supplied C8 ceramide elevated the …

Sphingolipids in early viral replication and innate immune activation

J Bezgovsek, E Gulbins, SK Friedrich, KS Lang… - Biological …, 2018 - degruyter.com
… A synthetic C8 ceramide has been shown to increase the expression of DC maturation
markers after infection with LCMV or influenza and thereby to stimulate the expansion of …

[HTML][HTML] Ceramides promote apoptosis for virus-infected lymphoma cells through induction of ceramide synthases and viral lytic gene expression

L Dai, J Trillo-Tinoco, A Bai, Y Chen, J Bielawski… - Oncotarget, 2015 - ncbi.nlm.nih.gov
… specific ceramide/dh-ceramide species and related ceramide … several specific ceramide
and dihydro(dh)-ceramide species and … ceramide can be generated via de novo synthesis by …

Galactosyl ceramide or a derivative is an essential component of the neural receptor for human immunodeficiency virus type 1 envelope glycoprotein gp120.

S Bhat, SL Spitalnik… - Proceedings of the …, 1991 - National Acad Sciences
virus in the nervous system.' Recombinant gpl20, an envelope glycoprotein of human
imnmunodeficiency virus type … the linkage between galactose and ceramide is essential for binding…

[HTML][HTML] Glucosylceramide synthase maintains influenza virus entry and infection

K Drews, MP Calgi, WC Harrison, CM Drews… - PloS one, 2020 - journals.plos.org
… to decreased influenza virus infection [23–25,34]. Conversely, reductions in ceramide
synthesis through inhibition of ceramide synthase led to an increase in influenza virus replication […

Sphingomyelin is essential for the structure and function of the double-membrane vesicles in hepatitis C virus RNA replication factories

H Gewaid, H Aoyagi, M Arita, K Watashi… - Journal of …, 2020 - Am Soc Microbiol
ceramide transfer protein (CERT), which is in the SM biosynthesis pathway, are essential for
the biosynthesis of double-membrane vesicles (DMVs), the sites of viralceramide synthesis