… represents a major outlet for newly synthesized ceramides, we reasoned that flux between
… ceramide by neutral SMase was partially responsible for the activity of ceramide during viral …

… the newly synthesized viral particles … virus via ceramide flux—a key mediator of Zika infection
[59]. A recent study demonstrated that Zika virus requires host glycosphingolipids for viral …

… The pathway for ceramide synthesis in the ER of S. cerevisiae is similar to mammals, except
that sphinganine is hydroxylated by Sur2p to produce phytosphingosine, which in turn is N-…

… In the present study, we have demonstrated the direct involvement of the vSPT enzyme in
rewiring host ceramide synthesis. However, the viral genome also encodes for CerS and …

… a protein kinase important in anti-viral host defense mechanisms and recently implicated in
cellular stress pathways, results in the inhibition of protein synthesis as a prelude to cell death…

… Ceramide concentrations are also elevated in cells infected with human immunodeficiency
virus … The de novo synthesis of ceramide is stimulated by retinoic acid, by the exchange of …

… Initial studies on viral budding from cultured polarized epithelial cells showed a differential
… Although glycolipids are synthesized by a series of glycosyl transferases which add sugars …

… synthesis, sphingomyelin hydrolysis, and the salvage pathway [6, 7]. In the de novo biosynthetic
pathway, ceramide synthesis is … The role of ceramides was further extended beyond viral …

… Thus, we propose the model that CERT extracts newly synthesized ceramide from the ER
and carries the ceramide molecule, in a non-vesicular manner, to the Golgi apparatus. As a …

… Ceramide kinase (CERK) is a critical mediator of eicosanoid synthesis, and its product,
ceramide-1-… synthesis and uses a ceramide “pool” transported in an active manner via CERT. …