… Furthermore, volume overload produced in a mouse model … in the failing heart due to volume
overload, the aim of the … in the AV shunt model of volume overload. In addition, this study …

… We have previously shown that there occurred a downregulation in the Akt dependent
survival signal involving Bcl-2 whereas the pro-apoptotic protein BAX was upregulated in the …

… Most load-related signaling pathways assessed in this study predominate in pressure but not
volume overload. The stimulus-… We found the survival rate to be higher in AR mice (Fig. 1). …

… is initially well tolerated, but after 12–15 weeks, congestion and heart failure signs such as
… volume after acute volume overload might be associated with poorer short-term survival [109…

… volume just to maintain normal resting forward cardiac output. It is these structural defects that
place a chronic volume overload … volume, each presents a unique type of volume overload …

… survival signaling kinases extracellular signal-regulated kinase 1/2 and AKT, with no evidence
of cardiomyocyte apoptosis. β 1 -RB attenuated FA signaling … impairs FA signaling that …

… Specifically, we have noted perturbed matrix homeostasis, detrimental adrenergic signaling,
… cell growth, survival and myofibril assembly. As opposed to the volume overloaded MR heart…

… response and cellular signaling pathways were significantly enriched in the VO group,
whereas cardiac fibrosis, cytoskeletal pathway and G-protein signaling genes were enriched in …

… We examine mechanical scenarios of pressure- and volume overload, from the initial
insult, to compensated, and ultimately decompensated stage. We discuss how different …

… stress, that is, pressure overload (PO) and volume overload (VO).3 Hypertension or aortic …
, less adverse LV remodelling, and a better survival. These different phenotypes could be …