Renal-clearable probe with water solubility and photostability for biomarker-activatable detection of acute kidney injuries via NIR-II fluorescence and optoacoustic …

C Zeng, Y Tan, L Sun, Y Long, F Zeng… - Acs Applied Materials & …, 2023 - ACS Publications
Acute kidney injuries (AKI) have serious short-term or long-term complications with high
morbidity and mortality rate, thus posing great health threats. Developing high-performance NIR-…

Crystal nephropathies: mechanisms of crystal-induced kidney injury

SR Mulay, HJ Anders - Nature Reviews Nephrology, 2017 - nature.com
… wide range of kidney injuries that can lead to acute kidney injury, chronic kidney disease,
renal … Studies of the biology of crystal handling by the kidney have shown that the formation of …

Contrast-induced kidney injury: mechanisms, risk factors, and prevention

E Seeliger, M Sendeski, CS Rihal… - European heart …, 2012 - academic.oup.com
kidney injury is the leading life-threatening side effect of CM. Here, we highlight endpoints
used to assess CM-induced acute kidney injury (… comes about; the kidney medulla's unique …

Osmotic nephrosis: acute kidney injury with accumulation of proximal tubular lysosomes due to administration of exogenous solutes

M Dickenmann, T Oettl, MJ Mihatsch - American Journal of Kidney …, 2008 - Elsevier
… It has a broad clinical spectrum that includes acute kidney injury and chronic kidney failure
in rare cases. This article discusses the pathological characteristics, pathogenesis, and …

[HTML][HTML] Pathophysiology of acute kidney injury

DP Basile, MD Anderson, TA Sutton - Comprehensive Physiology, 2012 - ncbi.nlm.nih.gov
Acute kidney injury (AKI) is the leading cause of nephrology consultation and is associated
with high mortality rates. The primary causes of AKI include ischemia, hypoxia or …

Drug-induced acute kidney injury

M Schetz, J Dasta, S Goldstein… - Current opinion in critical …, 2005 - journals.lww.com
injury. Tubular toxicity is, at least in part, dose-dependent and is the cause of kidney injury
… Because indinavir is more water soluble at acidic pH, alkalinization is not recommended for …

Contrast-induced acute kidney injury

PA McCullough, JP Choi, GA Feghali… - Journal of the American …, 2016 - jacc.org
… Contrast is water soluble and freely filtered; however, its water solubility allows relatively
easy reabsorption by the proximal tubular cells, where it causes cellular damage (8). Recent …

[HTML][HTML] Kidney damage induced by repeated fine particulate matter exposure: Effects of different components

CS Yuan, CS Lai, GP Chang-Chien, YL Tseng… - Science of the Total …, 2022 - Elsevier
… We found that water-soluble extract … to kidney injury marker level elevation in mouse
kidneys. The lowest-observed-adverse-effect level for renal toxicity in mice was 40 μg water-soluble

Prevention of kidney injury following rhabdomyolysis: a systematic review

EJ Scharman, WG Troutman - Annals of Pharmacotherapy, 2013 - journals.sagepub.com
… Although Zager found that myoglobin was less soluble in acidic urine (precipitation of
myoglobin in urine was 4% at urine pH 7.5–6.5 and 73% at pH 5.0), he questioned the ferrihemate …

Kidney-targeted triptolide-encapsulated mesoscale nanoparticles for high-efficiency treatment of kidney injury

X Deng, T Zeng, J Li, C Huang, M Yu, X Wang… - Biomaterials …, 2019 - pubs.rsc.org
… Bad water solubility and undesired toxicity of triptolide (TP) still restrict its clinical
applications in renal diseases. In this work, well-defined, monodispersed, and uniform-sized TP-…