Analysis of heparin oligosaccharides by capillary electrophoresis–negative-ion electrospray ionization mass spectrometry

L Lin, X Liu, F Zhang, L Chi, IJ Amster, FE Leach… - Analytical and …, 2017 - Springer
… molecular weight heparin, and a low molecular weight heparin, using a … and negative-mode
electrospray ionization were optimized … The online CE hyphenated negative-ion electrospray

Capillary electrophoresis–mass spectrometry for the analysis of heparin oligosaccharides and low molecular weight heparin

X Sun, L Lin, X Liu, F Zhang, L Chi, Q Xia… - Analytical …, 2016 - ACS Publications
… oligosaccharides, ranging from disaccharides to low molecular weight heparins, … weight
heparin was demonstrated. Using normal polarity CE separation and positive-ion electrospray

Structural analysis of low molecular weight heparin by ultraperformance size exclusion chromatography/time of flight mass spectrometry and capillary zone …

Q Zhang, X Chen, Z Zhu, X Zhan, Y Wu… - Analytical …, 2013 - ACS Publications
… Although low molecular weight heparins (LMWHs) have been … size exclusion
chromatography/electrospray quadruple time-of-… Low molecular weight heparins (LMWHs) have …

Fragment profiling of low molecular weight heparins using reversed phase ion pair liquid chromatography-electrospray mass spectrometry

X Xu, D Li, L Chi, X Du, X Bai, L Chi - Carbohydrate research, 2015 - Elsevier
… Low molecular weight heparins (LMWHs) are linear and highly charged carbohydrate …
chemical or enzymatic depolymerization of heparin. Compared to unfractionated heparin (UFH), …

Complete molecular weight profiling of low-molecular weight heparins using size exclusion chromatography-ion suppressor-high-resolution mass spectrometry

J Zaia, K Khatri, J Klein, C Shao, Y Sheng… - Analytical …, 2016 - ACS Publications
… of heparin saccharides roughly up to degree-of-polymerization 20, leaving the high molecular
weight half … cell to desalt the chromatographic effluent online prior to the electrospray mass …

… chromatography-fluorescence detection-electrospray ionization-mass spectrometry separation and characterization of heparan sulfate, heparin, and low-molecular …

F Galeotti, N Volpi - Analytical chemistry, 2011 - ACS Publications
… (RP-HPLC)-fluorescence detector (Fd)-electrospray ionization-mass spectrometry (ESI…
heparin (Hep), heparan sulfate (HS), and various low-molecular-weight (LMW)-Hep using heparin

Quantitative determination of disaccharide content in digested unfragmented heparin and low molecular weight heparin by direct-infusion electrospray mass …

JE Camara, MB Satterfield, BC Nelson - Journal of pharmaceutical and …, 2007 - Elsevier
Heparins and low molecular weight heparins (LMWHs) are … In this work, a direct-infusion
electrospray ionization mass … known disaccharides in various native heparins and LMWHs after …

Bottom-up low molecular weight heparin analysis using liquid chromatography-Fourier transform mass spectrometry for extensive characterization

G Li, J Steppich, Z Wang, Y Sun, C Xue… - Analytical …, 2014 - ACS Publications
… Ultraperformance size exclusion chromatography/electrospray quadruple time-of-flight-…
hydrophilic interaction chromatography (HILIC)-Fourier transform-(FT) electrospray ionization-…

Ion-pairing reversed-phased chromatography/mass spectrometry of heparin

J Henriksen, P Roepstorff, LH Ringborg - Carbohydrate research, 2006 - Elsevier
… on-line ion-pairing reverse-phased chromatography electrospray ionisation (ESI) mass …
weight heparin preparation, whereas the other system can be used to separate isomeric heparin

… combinatorial libraries: developing a mass spectrometry-based strategy for characterization of anti-thrombin interaction with low molecular weight heparin and heparin …

RR Abzalimov, PL Dubin, IA Kaltashov - Analytical chemistry, 2007 - ACS Publications
… While electrospray ionization (ESI) MS alone is capable of providing meaningful … weight
heparin-derived therapeutic, Tinzaparin. We demonstrate that AT binding-competent heparin