Papillary thyroid carcinoma (PTC) is a malignant epithelial tumor showing follicular differentiation and distinctive nuclear features.¹ Papillary thyroid carcinoma is the most common thyroid carcinoma, accounting for 80% of thyroid carcinomas.² Numerous variants of PTC have been described, some of which behave more aggressively than conventional PTC. Three distinct molecular alterations are associated with PTC and are mutually exclusive.³ These include somatic BRAF point mutations, RET/PTC rearrangements, and somatic RAS point mutations. These molecular alterations are also associated with particular clinicopathologic features of PTC as well as particular subtypes of PTC.