… syndromes. Recent findings provide additional support for the concept that there is an aberration
of connective tissue metabolism in Werner's syndrome, but … in Werner's syndrome might …

… , connective tissue and endocrine-metabolic systems) similar to normal ageing at an early
stage of their life, followed by death at an average age of 46. The sequential appearance of …

… WS may cause abnormalities of connective tissue metabolism which are seldom seen in
normal … findings, Werner's syndrome is assumed to be a disorder of systemic connective tissue …

… At least 3 systems (the connective tissue, endocrine-metabolic, and immune systems) are
included in this process. The incidence of malignancy, especially of mesenchymal origin (…

… collagen metabolism was suggested.However, studies of connective tissue metabolism in …
proposed by the International Registry of Werner Syndrome group, as follows, with permission …

… WS patients suffer prematurely from a variety of age-related diseases in one or more of the
body’s major systems (nervous, immune, connective tissue, and endocrinemetabolic systems)…

… replacement of the subcutaneous tissue by hyalinized connective tissue. Chemical analysis
… metabolism in red blood cells. The high incidence of diabetes mellitus in Werner’s syndrome …

… in the human genome, and Werner syndrome is attributed to autosomal recessive mutations
in the … of connective tissue metabolism, and usually characterized by premature aging [10]. …

… and calcium metabolism in Werner's syndrome with special … metabolism in this disease.
We found less bone thickness in peripheral cortical bone in both sexes with Werner's syndrome …

… The density and organization of the collagenous connective tissue was altered variably … or
proteoglycan metabolism,79 sug¬ gest that a substantial component of the Werner's syndrome …