Werner syndrome: clinical features, pathogenesis and potential therapeutic interventions

J Oshima, JM Sidorova, RJ Monnat Jr - Ageing research reviews, 2017 - Elsevier
… One prominent example is our work to better define patients with “atypical Werner syndrome
(AWS)”. These patients were suspected to have WS on clinical grounds, but were found on …

The clinical characteristics of Werner syndrome: molecular and biochemical diagnosis

M Muftuoglu, J Oshima, C von Kobbe, WH Cheng… - Human genetics, 2008 - Springer
Werner patients. Also recommended are annual ophthalmologic examinations for cataracts
and the monitor for the cardiovascular diseases with particular attention to signs of angina. …

Spectrum and risk of neoplasia in Werner syndrome: a systematic review

JM Lauper, A Krause, TL Vaughan, RJ Monnat Jr - PloS one, 2013 - journals.plos.org
… of 189 well-documented Werner syndrome (WS) patients with 248 neoplasms. This population
included 139 Japan-resident patients, and an additional 50 patients of diverse ethnicities …

Research on werner syndrome: Trends from past to present and future prospects

K Tsuge, A Shimamoto - Genes, 2022 - mdpi.com
… Given these facts and speculations, are LECs in fact involved in developing cataracts in
patients with Werner’s syndrome? The length of telomere in LECs in old rats is shorter than that …

[PDF][PDF] Werner syndrome

RJ Monnat Jr - WHO/IARC Monograph on Pathology and …, 2002 - depts.washington.edu
… WS patients with 247 neoplasms reported between 1939 and 2011, where 139 patients were
… This cohort included 139 resident in Japan WS patients and 50 patients from a diversity of …

What can we learn from Werner syndrome? A biased view from a rheumatologist

M Goto - Modern rheumatology, 2002 - Taylor & Francis
… observed in Werner syndrome is depicted. For comparison with the patients outside
Japan (… peripheral blood lymphocytes in Werner syndrome patients. Hum Genet 1990;84:249–52. …

[PDF][PDF] Syndrome-causing mutations in Werner syndrome.

M Goto - Bioscience trends, 2008 - researchgate.net
… and other genetic diseases including Klinefelter syndrome in 2 patients, retinitis pigmentosa
in 3, Wilson's disease in 1, xeroderma pigmentosum in 3, and porokeratosis Mibelli in 1. …

Werner syndrome: a changing pattern of clinical manifestations in Japan (1917~ 2008)

M Goto, Y Ishikawa, M Sugimoto, Y Furuichi - Bioscience trends, 2013 - jstage.jst.go.jp
… As ~75% of the Werner syndrome (WS) patients recognized between 1904 and 2008 all
over the world are of Japanese origin, the most case reports and clinical studies on WS has …

Molecular biology of Werner syndrome

A Shimamoto, M Sugimoto, Y Furuichi - International journal of clinical …, 2004 - Springer
Werner syndrome (WS) is a rare autosomal recessive genetic disorder, and patients with
WS at a young age have various phenotypes or symptoms related to natural aging.Because …

Diagnostic criteria for Werner syndrome based on Japanese nationwide epidemiological survey

M Takemoto, S Mori, M Kuzuya… - Geriatrics & …, 2013 - Wiley Online Library
… Aim: Werner syndrome (WS) is an autosomal recessive … revise the diagnostic criteria for
Japanese Werner syndrome. … A bird-like face is typically seen in Werner syndrome patients