Werner Syndrome, aging and cancer

A Ozgenc, LA Loeb - Genome and Disease, 2006 - karger.com
… the molecular studies on Werner syndrome, an intriguing … The major motivation in studying
Werner syndrome as a model … of two patients displaying the typical features of the Werner

The Werner syndrome protein is involved in RNA polymerase II transcription

AS Balajee, A Machwe, A May, MD Gray… - Molecular biology of …, 1999 - Am Soc Cell Biol
Werner syndrome (WS) is a human progeroid syndrome … these patients with increased
frequency. The symptoms of WS begin to appear around the age of puberty, and most patients die …

Werner's syndrome with a report of two cases

GW Irwin, PB Ward - The American Journal of Medicine, 1953 - Elsevier
… in the literature eleven patients were considered to have diabetes mellitus. Our patients did
not … for the second patient and was slightly elevated for the first patient who had the greater …

Werner syndrome: characterization of mutations in the WRN gene in an affected family

C Meisslitzer, W Ruppitsch… - European Journal of …, 1997 - karger.com
… Two brothers, 35 and 26 years at the time of biopsy, were diagnosed clinically as typical
Werner syndrome patients by their appearance (short stature: 165 cm; 157 cm, bird-like face, …

The Werner syndrome: a model for the study of human aging

JO Nehlin, GL Skovgaard… - Annals of the New York …, 2000 - Wiley Online Library
… recessive disorder known as the Werner syndrome (WS), which … The average life span of
WS patients is 47 years of age; and … Certain other features are very common in WS patients but …

Cytogenetic studies using various clastogens in two patients with Werner syndrome and control individuals

E Gebhart, M Schinzel, KW Ruprecht - Human genetics, 1985 - Springer
… frequency of spontaneous chromosome damage in the patients' cells as compared with
normal cells, the two cases of Werner syndrome described in the present study must be …

Werner syndrome presenting as early‐onset diabetes: A case report

X Wang, S Liu, F Qin, Q Liu… - Journal of Diabetes …, 2022 - Wiley Online Library
… onset in patients’ 30–40s. Herein, we report a Chinese patient with Werner syndrome with
… The present case reminds clinicians that when young diabetes patients are encountered, if …

Calcaneal osteosarcoma associated with Werner syndrome: a case report with mutation analysis

Y Tsuji, K Kusuzaki, K Kanemitsu, T Matsumoto… - JBJS, 2000 - journals.lww.com
patient with Werner syndrome and osteosarcoma whose diagnosis was confirmed by mutation
analysis. As 75 percent of alleles of Japanese patients with Werner syndrome … Our patient

Immunologic studies on Werner's syndrome.

Y Nakao, T Hattori, K Takatsuki, Y Kuroda… - Clinical and …, 1980 - ncbi.nlm.nih.gov
… It is interesting that some of our patients with Werner's syndrome exhibited characteristics
such as serum NTA, a significant reduction in PWM-induced B cell differentiation and a slightly …

Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy

SG Chun, NS Yee - Cancer biology & therapy, 2010 - Taylor & Francis
Advanced age is considered a risk factor of pancreatic cancer, but this relationship at the
molecular and genetic level remains unclear. We present a clinical case series focusing on an …