Four susceptibility loci for gallstone disease identified in a meta-analysis of genome-wide association studies

AD Joshi, C Andersson, S Buch, S Stender, R Noordam… - Gastroenterology, 2016 - Elsevier
… of gallstone disease, there are few replicated susceptibility loci identified from genome-wide, …
In this study, we therefore conducted a large-scale GWAS meta-analysis in individuals with …

[PDF][PDF] Genome‐wide analysis identifies gallstonesusceptibility loci including genes regulating gastrointestinal motility

CJ Fairfield, TM Drake, R Pius, AD Bretherick… - …, 2022 - Wiley Online Library
… the formation of gallstones, there have been no gallstonesusceptibility variants identified that
… knowledge of gallstone formation. The most recent GWAS and GWAS meta- analysis used …

Loci from a genome-wide analysis of bilirubin levels are associated with gallstone risk and composition

S Buch, C Schafmayer, H Völzke, M Seeger, JF Miquel… - Gastroenterology, 2010 - Elsevier
gallstone disease include age, female sex, and body mass index.2, 8 A genetic component
in the susceptibility to gallstones … Likewise, genome-wide linkage analyses of gallstone traits …

Obesity, adiposity, and risk of symptomatic gallstone disease according to genetic susceptibility

J Lim, J Wirth, K Wu, E Giovannucci, P Kraft… - Clinical …, 2022 - Elsevier
… The role of cholesterol supersaturation in gallstone formation was further supported by … with
gallstone disease susceptibility discovered through a large genome-wide association study (…

A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease

S Buch, C Schafmayer, H Völzke, C Becker, A Franke… - Nature …, 2007 - nature.com
… Genome-wide studies of gallstone susceptibility in inbred mouse strains established a …
-wide linkage analysis of Mexican American families identified a gallstone susceptibility locus on …

[HTML][HTML] Genome-wide association meta-analysis yields 20 loci associated with gallstone disease

E Ferkingstad, A Oddsson, S Gretarsdottir… - Nature …, 2018 - nature.com
… Interestingly, we observe opposing effects of the FUT2 variant rs601338 on the risk of
gallstone disease and susceptibility to gastrointestinal infection. This constitutes an example of …

Cholesterol gallstone susceptibility loci: a mouse map, candidate gene evaluation, and guide to human LITH genes

MA Lyons, H Wittenburg - Gastroenterology, 2006 - Elsevier
… to postulate causal roles for genes in gallstone susceptibility. Unfortunately, few such genes
analysis of literature to support or refute the contributions to gallstone susceptibility by genes …

[PDF][PDF] Identification and replication of six loci associated with gallstone disease

H Gellert‐Kristensen, N Dalila… - …, 2019 - Wiley Online Library
… transporter ABCB4 and gallstone disease was identified in an … (5) The latest gallstone
GWAS included 8,720 gallstone … to identify genetic susceptibility loci for gallstone disease. The …

[HTML][HTML] Blood lipid metabolism and the risk of gallstone disease: a multi-center study and meta-analysis

M Zhang, M Mao, C Zhang, F Hu, P Cui, G Li… - Lipids in Health and …, 2022 - Springer
… When cholecystectomy and gallstones were analyzed separately, the higher concentrations
… LDL cholesterol was related to a high susceptibility to gallstones formation. The high level of …

Genetics of gallstone disease

C Rebholz, M Krawczyk… - European journal of clinical …, 2018 - Wiley Online Library
… A large meta-analysis of GWAS of 15,241 women with European ancestry, using the Human
… Furthermore, another meta-analysis of GWAS27 identified additional susceptibility loci for …