… stratification in Wilms tumors requires multisampling. We have shown that Wilms tumor (WT),
the commonest pediatric kidney cancer, shows a range of evolutionary trajectories. We also …

… ensure adequate representation of the tumor’s genetics. Finally, we describe a truncating
PPM1D mutation that was associated with clonal evolution of the tumor. Early detection of …

… and surveillance of patients with Wilms tumor. Moreover, if we … of clonal nephrogenesis,
prevention of Wilms tumor could become feasible. Collectively, our findings portray Wilms tumor …

… Clonal evolution within and across anatomic compartments Wilms tumors typically consist
of one or several tumor nodules, … We sought to compare clonal evolution happening within …

… Four patterns of clonal evolution underlying intratumoural heterogeneity that are common
to Wilms tumour, neuroblastoma and rhabdomyosarcoma have been identified 34 . The most …

… This analysis showed that Wilms tumors overall have a shorter stem length than
neuroblastomas and rhabdomyosarcomas (Supplementary Table S1; P = 0.009; two-sided Mann–…

… Early passage WTPDX show evidence of clonal selection, clonal evolution and enrichment
of blastemal gene expression. Favorable histology WTPDX are sensitive, whereas …

… anaplastic cells arise from clonal progression of cells showing … tumor speci mens. Our results
support the notion that disrupting cell turnover plays an important role in tumor progression …

… distinct Wilms tumors within a single mass in Case 13. The phylogenetic tree shows the
evolutionary relationship between the normal kidney sample (NK, green node) and tumor …

… Overall, this study sheds light on the evolution of the most common paediatric kidney
cancer and links 23 evolutionary analysis to fundamental clinical and biological questions in a …