Divergent behavioral responses in protracted opioid withdrawal in male and female C57BL/6J mice

IM Bravo, BR Luster, ME Flanigan… - European Journal of …, 2020 - Wiley Online Library
… Here, we report that 6 weeks following morphine exposure and withdrawal we find
significant increases in anxiety-like behavior in male and female morphine-treated C57BL/6J …

[HTML][HTML] Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice

AD Dunn, SA Robinson, C Nwokafor, M Estill… - Frontiers in Behavioral …, 2023 - frontiersin.org
mouse model of in utero and post-natal opioid exposure, and subsequent neonatal opioid
withdrawalMice that were exposed to morphine throughout all 3-human equivalent trimesters …

Chronic escalating cocaine exposure, abstinence/withdrawal, and chronic re-exposure: effects on striatal dopamine and opioid systems in C57BL/6J mice

Y Zhang, SD Schlussman, J Rabkin, ER Butelman… - …, 2013 - Elsevier
… administration, 14-day withdrawal and then 14-day re-exposure to escalating-dose binge …
activity of each mouse in each period (exposure, withdrawal and re-exposure), Condition × …

Different affective response to opioid withdrawal in adolescent and adult mice

SR Hodgson, RS Hofford, PJ Wellman, S Eitan - Life sciences, 2009 - Elsevier
opioid withdrawal. FST behaviors are classically used to evaluate mood in rodents, thus this
study suggests that opioid withdrawal … the effects of opioid exposure during adolescence …

Effects of opioid tolerance and withdrawal on the immune system

TK Eisenstein, RT Rahim, P Feng… - Journal of Neuroimmune …, 2006 - Springer
… of opioid exposure on immune function. The reason kinetic assessments of effects of opioids
… of spleen cells from placebo withdrawn or morphine withdrawn mice with normal cells were …

Modeling spontaneous opioid withdrawal in male and female outbred mice using traditional endpoints and hyperalgesia

AL Brewer, CC Lewis, L Eggerman… - Behavioural …, 2023 - journals.lww.com
withdrawal in outbred male and female mice that can be used to examine sex differences in
male and female mice … the knowledge that opioid exposure and withdrawal can contribute to …

Loss of morphine-induced analgesia, reward effect and withdrawal symptoms in mice lacking the µ-opioid-receptor gene

HWD Matthes, R Maldonado, F Simonin, O Valverde… - Nature, 1996 - nature.com
… A tendency to hypolocomotion was seen in homozygous mutant mice when they were
exposed to locomotor activity boxes during the first two habituation sessions. This response was …

Neurobehavioral effects of neonatal opioid exposure in mice: influence of the OPRM1 SNP

SA Robinson, AD Jones, JK Brynildsen… - Addiction …, 2020 - Wiley Online Library
… To determine whether this SNP modulates the neurobehavioral effects of neonatal opioid
exposure and withdrawal, we used mice possessing the equivalent Oprm1 SNP (A112G). …

[PDF][PDF] Opioid withdrawal behavior in spiny mice: A novel preclinical model of neonatal opioid withdrawal syndrome (NOWS)

S Stevens, S Mohan - Heliyon, 2021 - cell.com
… that prenatal morphine exposure in spiny mice led to an increase in withdrawal behavior …
long-term consequences of prenatal opioid exposure on neurodevelopment and behavior. …

Identifying the neurodevelopmental differences of opioid withdrawal

NJ van den Hoogen, CHT Kwok, T Trang - Cellular and molecular …, 2021 - Springer
opioid withdrawal in neonatal, adolescent and adult mice. We compare the behavioural
consequences of opioid withdrawal and … exposure is the most common cause of clinical neonatal …