Betulinic acid accelerates diabetic wound healing by modulating hyperglycemia-induced oxidative stress, inflammation and glucose intolerance

W Xie, W Hu, Z Huang, M Li, H Zhang, X Huang… - Burns & …, 2022 - academic.oup.com
… and mechanism for the beneficial effect of betulinic acid (BA) on diabetic wound healing. …
injury healing in diabetic rats. We conclude that BA accelerates diabetic burn injury healing by …

[HTML][HTML] Anti-inflammatory activities of betulinic acid: a review

JF Oliveira-Costa, CS Meira, MVG Neves… - Frontiers in …, 2022 - frontiersin.org
Betulinic acid, a lupane-type pentacyclic triterpene, is a … The potential of betulinic acid and
its derivatives has been shown in a … Here we reviewed the potential use of betulinic acid as a …

[HTML][HTML] The wound healing properties of betulin from birch bark from bench to bedside

A Scheffler - Planta medica, 2019 - thieme-connect.com
… The scientific interest in triterpenes such as betulin and its closest relatives has risen …
Medicine magazine about the discovery of betulinic acid counteracting malignant melanoma [7]. …

Healing effect of Dillenia indica fruit extracts standardized to betulinic acid on ultraviolet radiation-induced psoriasis-like wounds in rats

MR Kviecinski, IMB David, FS Fernandes… - Pharmaceutical …, 2017 - Taylor & Francis
betulinic acid. Table 1 shows the calculated concentrations of betulinic acid in AEE and EAE,
and the total of betulinic acid … Figure 4(G) illustrates the evolution of wound healing in rats …

[HTML][HTML] Betulinic acid enhances the viability of random-pattern skin flaps by activating autophagy

J Li, G Bao, E ALyafeai, J Ding, S Li, S Sheng… - Frontiers in …, 2019 - frontiersin.org
… with dimethyl sulfoxide, betulinic acid, and betulinic acid plus 3-… Betulinic acid promoted
survival of the skin flap area, … that betulinic acid improves survival of random-pattern skin flaps …

Betulinic acid and its derivatives: A patent review (2008–2013)

R Csuk - Expert opinion on therapeutic patents, 2014 - Taylor & Francis
… Increase of betulinic acid production in Saccharomyces cerevisiae by balancing fatty
acids and betulinic acid forming pathways. Appl Microbiol Biotechnol 2014; doi: 10.1007/s00253-…

[HTML][HTML] From a traditional medicinal plant to a rational drug: understanding the clinically proven wound healing efficacy of birch bark extract

S Ebeling, K Naumann, S Pollok, T Wardecki… - Plos one, 2014 - journals.plos.org
… of its wound healing properties as … (betulin, lupeol, betulinic acid, oleanolic acid and
erythrodiol). We demonstrate that TE and betulin influence the inflammatory phase of wound healing

Betulinic acid: a natural product with anticancer activity

S Fulda - Molecular nutrition & food research, 2009 - Wiley Online Library
Betulinic acid (BA) is a naturally occurring pentacyclic triterpene that exhibits a variety of
biological activities including potent antitumor properties. This anticancer activity has been …

Betulinic acid: recent advances in chemical modifications, effective delivery, and molecular mechanisms of a promising anticancer therapy

M Ali‐Seyed, I Jantan, K Vijayaraghavan… - Chemical biology & …, 2016 - Wiley Online Library
… , betulin can be converted to BetA in good yield using either of two different methods. In the
first method, betulin is first oxidized to betulinic acid (… are natural products and wound healing. …

The efficacy of betulinic acid in triple-negative breast cancer

D Weber, M Zhang, P Zhuang, Y Zhang… - SAGE Open …, 2014 - journals.sagepub.com
… Here, we report that betulinic acid was able to inhibit the inflammatory response, inhibit
angiogenesis and cause cell cycle arrest ultimately causing apoptosis in triple-negative breast …