Control of stem cell renewal and fate by YAP and TAZ
JH Driskill, D Pan - Nature Reviews Molecular Cell Biology, 2023 - nature.com
… we discuss how YAP/TAZ control stem cell fate … YAP/TAZ mediate stem cell decisions
between renewal and fate. We systematically analyse the role of YAP/TAZ from totipotent stem cells …
between renewal and fate. We systematically analyse the role of YAP/TAZ from totipotent stem cells …
YAP and TAZ in epithelial stem cells: A sensor for cell polarity, mechanical forces and tissue damage
A Elbediwy, ZI Vincent‐Mistiaen, BJ Thompson - Bioessays, 2016 - Wiley Online Library
… Yet, how YAP and TAZ are physiologically regulated remains unclear. Here we review …
that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells …
that YAP and TAZ act primarily as sensors of epithelial cell polarity, being inhibited when cells …
An imbalance in TAZ and YAP expression in hepatocellular carcinoma confers cancer stem cell–like behaviors contributing to disease progression
H Hayashi, T Higashi, N Yokoyama, T Kaida… - Cancer research, 2015 - AACR
… Thus, the shift from TAZ into YAP expression upregulated cancer stem cell markers, such
as CD90 and CD13, and conferred cancer stem cell–like properties represented by …
as CD90 and CD13, and conferred cancer stem cell–like properties represented by …
Context-dependent roles of YAP/TAZ in stem cell fates and cancer
… Stem cells and cancer are relevant systems for this undertaking, … on how YAP and TAZ
regulate cell fate in stem cells and … Functions of YAP in embryogenesis, stem cell fate and …
regulate cell fate in stem cells and … Functions of YAP in embryogenesis, stem cell fate and …
The role of YAP transcription coactivator in regulating stem cell self-renewal and differentiation
I Lian, J Kim, H Okazawa, J Zhao, B Zhao… - Genes & …, 2010 - genesdev.cshlp.org
… Elevated YAP protein levels and gene amplification have … we report that YAP is inactivated
during embryonic stem (ES) cell … , both YAP and TAZ are new factors that contribute to ES cell …
during embryonic stem (ES) cell … , both YAP and TAZ are new factors that contribute to ES cell …
TAZ: a β-catenin-like molecule that regulates mesenchymal stem cell differentiation
JH Hong, MB Yaffe - Cell cycle, 2006 - Taylor & Francis
… We propose that TAZ, as well as a highly related molecule YAP, are functionally, though
not structurally, similar to β-catenin and integrate extracellular, membrane, and cytoskeletal-…
not structurally, similar to β-catenin and integrate extracellular, membrane, and cytoskeletal-…
An overview of signaling pathways regulating YAP/TAZ activity
BC Heng, X Zhang, D Aubel, Y Bai, X Li, Y Wei… - Cellular and Molecular …, 2021 - Springer
… In the case of bone marrow-derived mesenchymal stem cells (BMSCs), increased YAP/TAZ
activation on a stiff substrate leads to enhancement of osteogenic differentiation [11]. …
activation on a stiff substrate leads to enhancement of osteogenic differentiation [11]. …
Injury-mediated stiffening persistently activates muscle stem cells through YAP and TAZ mechanotransduction
… proliferation, as YAP and TAZ translocation from … YAP and TAZ nuclear import with verteporfin,
a small-molecule inhibitor of YAP and TAZ, which up-regulates 14-3-3σ to sequester YAP …
a small-molecule inhibitor of YAP and TAZ, which up-regulates 14-3-3σ to sequester YAP …
[HTML][HTML] Regulation and mechanism of YAP/TAZ in the mechanical microenvironment of stem cells (Review) Erratum in/10.3892/mmr. 2021.12265
Y Li, J Wang, W Zhong - Molecular medicine reports, 2021 - spandidos-publications.com
… mechanical signals regulate YAP/TAZ activity in stem cells is not … of the mechanisms involved
in YAP/TAZ regulation on the … /Slug-YAP/TAZ complex to control stem cell function (65). …
in YAP/TAZ regulation on the … /Slug-YAP/TAZ complex to control stem cell function (65). …
Mechanobiology of YAP and TAZ in physiology and disease
T Panciera, L Azzolin, M Cordenonsi… - … reviews Molecular cell …, 2017 - nature.com
… YAP and TAZ mechanobiology in embryonic stem cells. YAP and TAZ and their regulation
by cell mechanics control the first cell fate decision in the mammalian embryo, namely, the …
by cell mechanics control the first cell fate decision in the mammalian embryo, namely, the …
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