… in organ size control. Once we decipher the mechanical and biochemical signals that control
the function of YAP and TAZ, we … in cancer treatment, tissue regrowth or organ regeneration. …

… Yes-associated protein (YAP)/TAZ transcription coactivators … YAP/TAZ inhibition affects cell
number by repressing cell proliferation and promoting apoptosis, thereby limiting organ size. …

… of organ size in both Drosophila and mammals. Acting downstream of the Hippo pathway
is the Yki/YAP/TAZ … the mechanism of YAP and TAZ in control of cell growth and organ size. …

… and the Hippo pathway may indeed represent a valuable target for cancer therapy and that
more opportunities will emerge as we learn more on the role of YAP/TAZ in organ growth and …

… -suppressor pathway in the regulation of organ size. Dysregulation of this pathway leads to
… organ size by phosphorylating and inhibiting the transcription co-activators YAP and TAZ in …

… YAP/TAZ activation (for simplicity, in this Review, we treat YAP and TAZ as equivalent proteins
(YAP/TAZ… ) in stimulating organ repair and regeneration in non-regenerating organs, with …

… In addition, these studies highlight the complexity of Yap/Taz regulation at the … organ size
regulation. Given the proposed importance of Yap and Taz in controlling mammalian organ size…

… In many cases, the regulation of organ size is achieved by systemic or ‘extrinsic’ factors, …
size. In Drosophila and mammals, the rate of growth and final organ size of developing organs …

Hippo signaling controls organ size and tumor progression through a conserved pathway
leading to nuclear translocation of the transcriptional effector Yki/Yap/Taz. Most of our …

… by YAP/TAZ is independent of mTOR. Instead, we find that YAP/TAZ directly impacts the cell
division volume, and YAP … Based on the idea that YAP/TAZ is a mechanosensor, we find that …