… of macrophage death during bulk infections in which two cellular … caspase-8–mediated
pyroptosis and suggest a hypothesis for the increased sensitivity of humans to Yersinia infection …

… The Yersinia virulence factor … caspase-8, RIPK1, and FADD are required for YopJ-induced
cell death and show that mice lacking caspase-8 are severely susceptible to Yersinia infection …

… Receptor-interacting protein-1 (RIP1) kinase and caspase-8 … that RIP1, caspase-8, and RIP3
contribute to infection-induced … how Yersinia induces macrophage cell death via caspase-8 …

… We hypothesized that the Yersinia T3SS actively or passively transports a caspase-1–activating
ligand into the macrophage cytosol. Recent studies with Salmonella and Legionella …

… and macrophages about 90 min post Yersinia infection [8–10], we wondered, … Yersinia-infected
DC (Fig. 2A) indicated that TNF-α was produced as early as 45 min after P-CA infection …

… apoptosis, caspase-1 activation, and secretion of IL-1β in Yersinia-infected macrophages. …
and activation of caspase-1 by YopJ KIM in Yersinia-infected macrophages was studied. Site …

… caspase-8 activation in Yersinia-infected macrophages comes from Bid cleavage assays.
Caspase-8 cleavage has been detected in Yersinia infected … Caspase-8 has been reported to …

… activation of RIPK1–caspase-8–dependent pyroptosis during Yersinia infection, we performed
an unbiased genome-wide CRISPR screen. We infected Cas9-expressing immortalized …

… Here, we report that caspase-8 plays an essential cell-intrinsic role in innate inflammatory
cytokine production in vivo during Yersinia infection. Unexpectedly, we found that caspase-8 …

… lack of inflammation to a markedly inflammatory host response and suggests the possibility
of threshold-gated host responses governing this key transition during Yersinia infections. …