… unknown aspects of the pathogen and its disease development. Here, we focus on some
of the knowns and unknowns relating to Y. pestis and plague. We notably focus on some key …

… pseudotuberculosis are still unknown but may reflect the fact that Y. pestis contains two
pestis-… The following, highly speculative evolutionary scenario invokes the known features of Y. …

… all of the “known world” at that time and later became known as the Black Death. Even the
… the real cause of the disease remained unknown and beside the concepts devel oped by …

… In addition, the genetic architecture of these modern strains is currently unknown, and
since little is known is about the structure of the ancient genome, we cannot currently assess …

… Although some of the numerous references to plagues in ancient texts may be attributable
to Yersinia pestis, the cycles of plague epidemics between 541 and 750 ADare called the first …

… , in contrast to the situation in the United States, remain unknown and are possibly linked
to the inability of Y. … pestis strains 5,700 years BP) is basal to all known modern and ancient …

… pestis for humans remains largely unknown, locked away in the multitude of strains … world
to summarize what is known about diversity in isolates of Y. pestis. Given the natural genetic …

… , but also that it was of a previously unknown strain. Moreover, the genetic data carried in its
… , although it is well known that if and when Yersinia pestis reaches the lungs it can cause …

… and growth in the macrophage are not known; however, Y. pestis has been shown to possess
a two-… YopE also disrupts the cytoskeleton by an unknown mechanism. In contrast, YopJ (…

… The node indicated as an asterisk marks the polytomy known as the «Big Bang», which …
disseminates from skin flea injection sites to lymph nodes was unknown and it was suspected …