Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
… of ZEB1 in mediating tumor progression and metastasis and describe the ways in which protein
modifications can regulate its molecular associations and function… regulation of ZEB1′s …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
ZEB1ZEB1 and these chromatin-modifying enzymes may represent an efficient for treating
cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic progression

[HTML][HTML] Expanding roles of ZEB factors in tumorigenesis and tumor progression

E Sánchez-Tilló, L Siles, O De Barrios… - American journal of …, 2011 - ncbi.nlm.nih.gov
… Evidence in the literature indicates that ZEB1 and ZEB2 play … its tumor progression role
discussed so far, ZEB1 inhibits tumor … to larger tumors with more tumor vessels—and higher ZEB1

Pleiotropic roles for ZEB1 in cancer

J Caramel, M Ligier, A Puisieux - Cancer research, 2018 - AACR
ZEB1 is a prime element of a network of transcription factors … Aberrant expression of ZEB1
has been reported in a variety … unsuspected intrinsic oncogenic functions of ZEB1 that impact …

[HTML][HTML] The curious case of ZEB1

M Madany, T Thomas, LA Edwards - Discoveries, 2018 - ncbi.nlm.nih.gov
… In vivo studies 38 have shown that tumors with increased ZEB1 and lowered E-Cadherin …
cementing the role of ZEB1 in EMT and tumor progression. This role of ZEB1 has been further …

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

O Schmalhofer, S Brabletz, T Brabletz - Cancer and Metastasis Reviews, 2009 - Springer
… In this context, ZEB1-mediated loss of the basement membrane contributes to tumor progression
and disturbance of tissue architecture in a dual fashion: by loosing a mechanical barrier …

Inactivation of endothelial ZEB1 impedes tumor progression and sensitizes tumors to conventional therapies

R Fu, Y Li, N Jiang, BX Ren, CZ Zang… - The Journal of …, 2020 - Am Soc Clin Investig
… of vascular ZEB1 in tumor progression, we evaluated LLC and B16F10 tumor models by
subcutaneous implantation of LLC and B16F10 cells into 9-week-old Zeb1 WT and Zeb1 iΔEC …

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
… mechanisms by which ZEB1 regulates tumor progression and treatment resistance. Based
on studies by us and others, we propose that it is specific EMT inducers like ZEB1, but not the …

Tumor‐associated macrophages (TAMs) depend on ZEB1 for their cancer‐promoting roles

M Cortés, L Sanchez‐Moral, O de Barrios… - The EMBO …, 2017 - embopress.org
… We then turned to investigate the molecular mechanisms by which the expression of ZEB1
in TAMs promotes an enhanced tumor progression in the ID8 cancer model. The CCL2-CCR2 …

ZEB1: New advances in fibrosis and cancer

L Cheng, MY Zhou, YJ Gu, L Chen, Y Wang - Molecular and Cellular …, 2021 - Springer
… structure of ZEB1 and the protein binding sites of ZEB1 with some … roles of ZEB1 in fibrosis
and cancer progression to elaborate … , ZEB1 facilitates tumor progression and promotes tumor