Regulation of ZEB1 function and molecular associations in tumor progression and metastasis

M Perez-Oquendo, DL Gibbons - Cancers, 2022 - mdpi.com
… of ZEB1 in mediating tumor progression and metastasis and describe the ways in which protein
modifications can regulate its molecular associations and function… regulation of ZEB1′s …

[HTML][HTML] The roles of ZEB1 in tumorigenic progression and epigenetic modifications

Y Zhang, L Xu, A Li, X Han - Biomedicine & Pharmacotherapy, 2019 - Elsevier
… for treating cancer. In this review, we outlined the biological function of ZEB1 in tumorigenic
progression and … In cancer progression, a crucial target of Wnt is the transcription factor …

[HTML][HTML] Expanding roles of ZEB factors in tumorigenesis and tumor progression

E Sánchez-Tilló, L Siles, O De Barrios… - … journal of cancer …, 2011 - ncbi.nlm.nih.gov
… Evidence in the literature indicates that ZEB1 and ZEB2 play … its tumor progression role
discussed so far, ZEB1 inhibits tumor … to larger tumors with more tumor vessels—and higher ZEB1

[HTML][HTML] ZEB1 promotes the progression and metastasis of cervical squamous cell carcinoma via the promotion of epithelial-mesenchymal transition

Y Ma, X Zheng, J Zhou, Y Zhang… - International Journal of …, 2015 - ncbi.nlm.nih.gov
… contributor to the process of malignant cancer progression. ZEB1 is encoded by the TCF8
gene … In this study, we detected ZEB1, E-cadherin, β-catenin and N-cadherin in tumors from 81 …

[HTML][HTML] ZEB1: catalyst of immune escape during tumor metastasis

J Lu, F Fei, C Wu, J Mei, J Xu, P Lu - Biomedicine & Pharmacotherapy, 2022 - Elsevier
ZEB1 expression and its role in tumor immune evasion, which may make it a promising
therapeutic target for tumor … acts as a driver of EMT and cancer progression. Aberrant expression …

ZEB1: at the crossroads of epithelial-mesenchymal transition, metastasis and therapy resistance

P Zhang, Y Sun, L Ma - Cell cycle, 2015 - Taylor & Francis
… cells that have undergone EMT acquire cancer stem cell properties … that ZEB1 regulates
radioresistance in breast cancer cells … by which ZEB1 regulates tumor progression and treatment …

[HTML][HTML] YTHDF3 facilitates triple-negative breast cancer progression and metastasis by stabilizing ZEB1 mRNA in an m6A-dependent manner

Y Lin, X Jin, Q Nie, M Chen, W Guo… - Annals of …, 2022 - ncbi.nlm.nih.gov
… The findings herein confirmed that the YTHDF3/ZEB1 axis plays an important role in the
progression and metastasis of TNBC. YTHDF3 is a promising prognosis biomarker and potential …

E-cadherin, β-catenin, and ZEB1 in malignant progression of cancer

O Schmalhofer, S Brabletz, T Brabletz - Cancer and Metastasis Reviews, 2009 - Springer
… cells to invade the stroma and subsequently to disseminate and metastasize [199]. In this
context, ZEB1-mediated loss of the basement membrane contributes to tumor progression and …

HN1L-mediated transcriptional axis AP-2γ/METTL13/TCF3-ZEB1 drives tumor growth and metastasis in hepatocellular carcinoma

L Li, YL Zheng, C Jiang, S Fang, TT Zeng… - Cell Death & …, 2019 - nature.com
… Furthermore, up-regulated METTL13 promotes tumor growth and metastasis by increasing …
-regulate TCF3 and ZEB1 that are known and vital regulators in tumor growth and metastasis. …

The transcriptional repressor ZEB1 promotes metastasis and loss of cell polarity in cancer

S Spaderna, O Schmalhofer, M Wahlbuhl, A Dimmler… - Cancer research, 2008 - AACR
role of ZEB1 in malignant tumor progression, we stably knocked down ZEB1 by short hairpin
RNA transfer in tumor cells expressing high levels of ZEB1 (see Supplementary data, Fig. …