The tandem CCCH zinc finger protein tristetraprolin and its relevance to cytokine mRNA turnover and arthritis

DM Carrick, WS Lai, PJ Blackshear - Arthritis Res Ther, 2004 - Springer
… The transcript encoding the tandem CCCH zinc finger (TZF) protein tristetraprolin (TTP) was
… of two nearly identical putative zinc fingers in the predicted protein sequence, and early data …

Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover

PJ Blackshear - Biochemical Society Transactions, 2002 - portlandpress.com
… Our laboratory first became involved in the study of tristetraprolin (TTP) and other CCCH
tandem zinc-finger proteins (ZFPs) more than 10 years ago. The object of a study carried out by …

Zinc finger protein tristetraprolin interacts with CCL3 mRNA and regulates tissue inflammation

JG Kang, MJ Amar, AT Remaley, J Kwon… - The Journal of …, 2011 - journals.aai.org
Zinc finger protein tristetraprolin (TTP) modulates macrophage inflammatory activity by …
The identification of tristetraprolin (TTP), encoded by the zinc finger protein 36 gene, as an …

The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family

WS Lai, ML Wells, L Perera… - Wiley Interdisciplinary …, 2019 - Wiley Online Library
protein family arose from an ancient ancestor. The defining characteristic of this protein family
is the tandem zinc finger (… We discuss here many aspects of this protein domain that have …

Targeting zinc finger proteins with exogenous metals and molecules: lessons learned from tristetraprolin, a CCCH type zinc finger

K Ok, MR Filipovic, SLJ Michel - European journal of inorganic …, 2021 - Wiley Online Library
… His research mainly focused on the CCCH-type zinc finger protein, tristetraprolin, which
is intimately involved in inflammation and immune responses. He will continue his academic …

Mutational and structural analysis of the tandem zinc finger domain of tristetraprolin

WS Lai, L Perera, SN Hicks, PJ Blackshear - Journal of Biological …, 2014 - ASBMB
Tristetraprolin (TTP), the best known member of a class of tandem (R/K)YKTELCX 8 CX 5
CX 3 H zinc finger proteins, … the tandem zinc finger (TZF) domain, in the ability of the full-length …

The RNA-binding zinc-finger protein tristetraprolin regulates AU-rich mRNAs involved in breast cancer-related processes

N Al-Souhibani, W Al-Ahmadi, JE Hesketh… - Oncogene, 2010 - nature.com
… by RNA-binding proteins, which are trans-acting factors that bind to AREs and regulate the
stability of ARE-mRNAs. Among those is tristetraprolin (TTP), an RNA-binding protein that is …

Interactions of CCCH zinc finger proteins with mRNA: binding of tristetraprolin-related zinc finger proteins to AU-rich elements and destabilization of mRNA

WS Lai, E Carballo, JM Thorn, EA Kennington… - Journal of Biological …, 2000 - ASBMB
… known zinc finger proteins containing two CCCH zinc fingersproteins are most closely
related in their tandem zinc finger … contained both zinc fingers resembled the intact protein in …

Role of the tristetraprolin (zinc finger protein 36 homolog) gene in cancer

G Gupta, M Bebawy, TJA Pinto… - Critical Reviews™ in …, 2018 - dl.begellhouse.com
… The mRNA-destabilizing protein tristetraprolin is suppressed in … Nuclear tristetraprolin acts
as a corepressor of multiple steroid … Tristetraprolin mediates the anti-proliferative effects of …

Cu (I) disrupts the structure and function of the nonclassical zinc finger protein tristetraprolin (TTP)

GD Shimberg, K Ok, HM Neu, KE Splan… - Inorganic …, 2017 - ACS Publications
Tristetraprolin (TTP) is a nonclassical zinc finger (ZF) protein that plays a key role in regulating
inflammatory response. TTP regulates cytokines at the mRNA level by binding to AU-rich …