… We describe the use of zinc-finger nucleases (ZFNs) for somatic and germline disruption
of … years have yielded a large number of zinc fingers aimed at recognizing investigator-specified …

… of a small family of CCCH tandem zinc finger proteins capable of binding to RNA. The CCCH
tandem zinc finger region in this family is characterized by 2 zinc fingers, spaced 18 amino …

… ), for cellular entry, targeting CCR5 expression is an attractive … zinc-finger protein nucleases
(ZFNs) specifically disrupting … encoding a zinc finger protein nuclease (ZFN) targeting the …

… possibility of targeted gene disruption and … targeted gene disruption in medaka using ZFNs.
We injected embryos from transgenic medaka strains with functional ZFN RNA that targeted …

… targeted modification of domestic animals. For the first time, we report the targeted disruption
… With the help of our surrogate reporter system, a targeted disruption efficiency was up to 2.5 …

Targeted disruption of Tbc1d20with zinc-finger nucleases causes cataracts and testicular …
Targeted disruption of Tbc1d20with zinc-finger nucleases causes cataracts and testicular …

… We demonstrate that zinc finger nucleases (ZFNs) introduced into fertilized oocytes can …
gene-targeting vector to achieve the first gene knockout and targeted sequence replacement in …

… to this problem: targeted gene disruption with designed zinc-finger nucleases (ZFNs). … a
zinc-finger protein (4, 5) that is engineered to bind a specific genomic locus to induce a targeted …

… targeting and disruption of an investigator-specified gene. Early approaches to somatic cell
gene disruption … more recent methods used targeted homologous recombination (HR) (3). …

… nucleases (ZFNs) have now been widely used for genome editing in many species and cell
types for basic science, biotechnology, and medical applications, such as targeted disruption …