… status and can increase the local oxidative stress in periodontium. Therefore, the objective
of this study was to evaluate whether the chronic infusion of Zoledronic Acid (ZA) increases …

… Cells are protected against oxidative damage by various systems (enzymatic and non-… can
cause oxidative damage to mitochondrial and cellular proteins, lipids, and nucleic acids, while …

… Zoledronic acid (ZLD) is a bisphosphonate drug widely administered against pathological
conditions such as hypercalcemia of malignancy, osteoporosis, bone metastases from solid …

… oxidative stress and bisphosphonate treatment in the oral epithelium of rats [15]. Surveys
showed that zoledronic acid … a direct relationship between oxidative stress and osteonecrosis in …

… In the present study, the molecular mechanism of zoledronic acid-related kidney damage
was evaluated. For this purpose, the cytotoxic and antiproliferative effects of zoledronic acid …

Objectives The aim of our work was to evaluate the role of nitric oxide (NO) in the in vitro
response of human gingival fibroblasts (HGFs) to 1, 5, 10, and 100 μM doses of zoledronic acid (…

… Zoledronic acid enhances lipopolysaccharide-stimulated proinflammatory reactions through
… Cytokines and insulin resistance after zoledronic acid-induced acute phase response. …

… Osteoclasts are very sensitive to oxidative stress 17,18,19 . Low levels of ROS may … to
elevated oxidative stress results in cytotoxic effects due to the increased oxidative damage of DNA, …

… Effect of zoledronic acid on PNT2 cell viability and different doses of X-irradiation (0, 10 and
… % zoledronic acid concentrations at 25 and 50 μl, respectively; Z100, 100 % zoledronic acid …

… In the current study, the role of Zoledronic acid (ZA), a kind of bisphosphonates, in suppressing
the growth of osteoclasts was investigated and its underlying mechanism was explored. …