A Semisynthetic Oligomannuronic Acid-Based Glycoconjugate Vaccine against Pseudomonas aeruginosa

Y Zhang, X Wang, Y Liang, L Zhang, J Fan… - ACS Central …, 2024 - ACS Publications
Pseudomonas aeruginosa is one of the leading causes of nosocomial infections and has
become increasingly resistant to multiple antibiotics. However, development of novel …

Efficacy of a conjugate vaccine containing polymannuronic acid and flagellin against experimental Pseudomonas aeruginosa lung infection in mice

VL Campodónico, NJ Llosa, LV Bentancor… - Infection and …, 2011 - Am Soc Microbiol
Vaccines that could effectively prevent Pseudomonas aeruginosa pulmonary infections in
the settings of cystic fibrosis (CF) and nosocomial pneumonia could be exceedingly useful …

Optimization of the Synthesis and Conjugation of the Methyl Rhamnan Tip of Pseudomonas aeruginosa A-Band Polysaccharide and Immunogenicity Evaluation for …

MP Jamshidi, C Cairns, N Huan Khieu… - ACS Infectious …, 2024 - ACS Publications
Pseudomonas aeruginosa is an antimicrobial-resistant bacterium that has no vaccine
approved for human use. Additionally, it has been identified by the World Health …

Synthesis and Immunogenicity of a Methyl Rhamnan Pentasaccharide Conjugate from Pseudomonas aeruginosa A-Band Polysaccharide

MP Jamshidi, C Cairns, S Chong… - ACS Infectious …, 2022 - ACS Publications
Pseudomonas aeruginosa was added to the World Health Organization's priority pathogen
list for research and development of new antibiotics in 2017. Alongside the development of …

Immunological evaluation of an alginate‐based conjugate as a vaccine candidate against Pseudomonas aeruginosa

A Farjah, P Owlia, SD Siadat, SF Mousavi… - Apmis, 2015 - Wiley Online Library
Pseudomonas aeruginosa is an opportunistic pathogen that causes serious infections, is
usually resistant to antimicrobial agents, and is the leading cause of morbidity and …

Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections

A DiGiandomenico, J Rao, K Harcher… - Proceedings of the …, 2007 - National Acad Sciences
Surface-expressed bacterial polysaccharides are often immunodominant, protective
antigens. However, these antigens are chemically and serologically highly heterogeneous …

Increased immunogenicity and protective efficacy of a P. aeruginosa vaccine in mice using an alum and de-O-acylated lipooligosaccharide adjuvant system

JI Ryu, SR Wui, A Ko, HTT Do, YJ Lee… - … of microbiology and …, 2017 - koreascience.kr
Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that commonly
causes fatal infections in cystic fibrosis and burn patients as well as in patients who are …

Monoclonal antibodies against lipopolysaccharide protect against Pseudomonas aeruginosa challenge in mice

J Kang, M Mateu-Borrás, HL Monroe… - Frontiers in Cellular …, 2023 - frontiersin.org
Pseudomonas aeruginosa is a common cause of hospital-acquired infections, including
central line-associated bloodstream infections and ventilator-associated pneumonia …

Conjugation of alginate to a synthetic peptide containing T-and B-cell epitopes as an induction for protective immunity against Pseudomonas aeruginosa

A Farjah, P Owlia, SD Siadat, SF Mousavi… - Journal of …, 2014 - Elsevier
Pseudomonas aeruginosa is a major cause of respiratory tract infections worldwide,
particularly in hospitalized patients with immunosuppressed conditions and cystic fibrosis …

Promoter-Controlled Synthesis and Antigenic Evaluation of Mannuronic Acid Alginate Glycans of Pseudomonas aeruginosa

L Zhang, Y Zhang, Q Hua, T Xu, J Liu, Y Zhu… - Organic …, 2022 - ACS Publications
Pseudomonas aeruginosa is a leading cause of urinary tract, pulmonary, and wound
infections and is becoming increasingly resistant to antibiotics. Here, we report the iodonium …