STING agonism turns human T cells into interferon‐producing cells but impedes their functionality
Abstract The cGAS‐STING (cyclic GMP‐AMP synthase‐stimulator of interferon genes) axis is
the predominant DNA sensing system in cells of the innate immune system. However …
the predominant DNA sensing system in cells of the innate immune system. However …
[HTML][HTML] IUPHAR ECR review: The cGAS-STING pathway: novel functions beyond innate immune and emerging therapeutic opportunities
X He, A Wedn, J Wang, Y Gu, H Liu, J Zhang… - Pharmacological …, 2024 - Elsevier
Stimulator of interferon genes (STING) is a crucial innate immune sensor responsible for
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
distinguishing pathogens and cytosolic DNA, mediating innate immune signaling pathways …
STING trafficking activates MAPK–CREB signaling to trigger regulatory T cell differentiation
The Type-I interferon (IFN-I) response is the major outcome of stimulator of interferon genes
(STING) activation in innate cells. STING is more abundantly expressed in adaptive T cells; …
(STING) activation in innate cells. STING is more abundantly expressed in adaptive T cells; …
[HTML][HTML] Signal strength of STING activation determines cytokine plasticity and cell death in human monocytes
D Kabelitz, M Zarobkiewicz, M Heib, R Serrano… - Scientific reports, 2022 - nature.com
The cyclic GMP-AMP synthase (cGAS)/stimulator of interferon genes (STING) pathway is a
cytosolic sensor of microbial and host-derived DNA and plays a key role in innate immunity …
cytosolic sensor of microbial and host-derived DNA and plays a key role in innate immunity …
Type-1 interferon-dependent and-independent mechanisms in cyclic GMP–AMP synthase–stimulator of interferon genes-driven auto-inflammation
KMJ Gao, A Marshak-Rothstein… - Current Opinion in …, 2023 - Elsevier
Highlights•STING has distinct functions in the endoplasmic reticulum and Golgi.•Trex1 LOF
myocarditis is dependent on cGAS–STING and Interferon regulatory factor 3 (IRF3) …
myocarditis is dependent on cGAS–STING and Interferon regulatory factor 3 (IRF3) …
[HTML][HTML] Conserved strategies for pathogen evasion of cGAS–STING immunity
JB Eaglesham, PJ Kranzusch - Current opinion in immunology, 2020 - Elsevier
Highlights•Pathogens evade cytosolic DNA sensing using divergent and overlapping
strategies to target cGAS, 2′ 3′-cGAMP, and STING.•Studies of pathogen mechanisms of …
strategies to target cGAS, 2′ 3′-cGAMP, and STING.•Studies of pathogen mechanisms of …
[HTML][HTML] Progress of cGAS-STING signaling in response to SARS-CoV-2 infection
Y Wu, M Zhang, C Yuan, Z Ma, W Li, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is an epidemic respiratory disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can cause infections in …
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that can cause infections in …
Cutting edge: activation of STING in T cells induces type I IFN responses and cell death
Stimulator of interferon genes (STING) was initially described as a sensor of intracellular
bacterial and viral DNA and a promising adjuvant target in innate immune cells; more …
bacterial and viral DNA and a promising adjuvant target in innate immune cells; more …
[HTML][HTML] Akt kinase-mediated checkpoint of cGAS DNA sensing pathway
Upon DNA stimulation, cyclic GMP-AMP synthase (cGAS) synthesizes the second
messenger cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon …
messenger cyclic GMP-AMP (cGAMP) that binds to the STING, triggering antiviral interferon …
[PDF][PDF] Snapshot: cGAS-STING signaling
SnapShot: CGAS-STING Signaling Page 1 3 Cell ???, ??MONTH?? ??DATE??, 200? ©200?
Elsevier Inc. DOI XXXXXXXXX See online version for ??????. S n a pS h o t: XXX X X X XX …
Elsevier Inc. DOI XXXXXXXXX See online version for ??????. S n a pS h o t: XXX X X X XX …