… Originally, it was only approved for intravenous (IV) … ], sedative properties of midazolam
and propofol were compared … found not to be inferior to midazolam or propofol. Furthermore, a …

… The clearance of intravenously administered midazolam from plasma is primarily a function
… MAC is lower with preterm infants than in term infants and increases with post conceptual age…

… suppression of the stress response in the midazolam group, or advantages in hemodynamic
… with a mean age of 35 weeks received fentanyl intravenously (median 5.9 μg/kg). The …

… A further population pharmacokinetic model for intravenous administration of midazolam in
neonates indicated that a major change in maturation of CYP3A activity occurs during the first …

… is only relevant in preterm neonates as phenobarbital was … and midazolam can be extrapolated
to (near-)term neonates in general. As … neonates could be even greater. Extrapolation to …

… midazolam and fentanyl use in term and preterm infants appeared safe and well-tolerated
in this small cohort of infants. … or fentanyl by other routes (eg intravenous). We used clinical …

… and pharmacodynamics (including toxicity) in preterm neonates … midazolam concentration–time
profiles in preterm neonates … preterm neonates following a a 15 mg/kg single intravenous …

… an increased bioavailability of midazolam because CYP3A … time after intravenous induction
is slower in neonates that in … very preterm infants, partially useful in older preterm infants, …

… useful in very preterm infants, partially useful in older preterm infants, and useful in full-term
infants. … Intravenous bolus of midazolam in neonates has been associated with hypotension; …

… In preterm neonates, overall expression of UGT appeared to be around 10% of that in adults.…
in this study, using an expanded intravenous midazolam dataset in pediatrics, indicated that …