… In recent years, we and other groups have extensively mapped an increasing number of
gene CpG islands aberrantly hypermethylated in cancer (11, 49). These now include examples …

… For example, we have identified hypermethylated CpG islands as a guide for cloning
candidate tumor suppressor genes in a chromosomal area frequently deleted in cancer, but in …

… In combination with CpG island microarrays, the technique was used to … aberrantly methylated
CpG islands in three myeloid leukemia cell lines. Interestingly, within all hypermethylation …

… The DNA methylomes of cancer cells can exhibit two striking differences from normal cells;
a global reduction of DNA methylation levels and the aberrant hypermethylation of some …

… DNA methylation has not yet been investigated in DN. Thus, information relating to CpG island
hypermethylation … study, we determined the methylation status of CpG islands, including 9 …

… Hypermethylation of CpG islands near gene promoter regions is associated with transcriptional
inactivation and represents an important mechanism of gene silencing in carcinogenesis…

… hypermethylation of these four CpG islands to address two separate issues: (a) in a limited
number of patients, we have determined which DNA methylation … these methylation changes …

… The importance of hypermethylation of CpG islands during tumour development has
been particularly highlighted by a number of examples in which epigenetic, and not genetic, …

… markers specifically associated with the CIMP-L subgroup, we examined 22 CpG sites that
showed significant DNA hypermethylation in CIMP-L tumors but not in CIMP-H tumors, as …

… DNA methylation status of CpG islands of genes previously cloned by … Aberrant
hypermethylation in cancer or leukemia cells may affect hundreds of promoter-associated CpG …