… The methylation status of IGF2/H19 DMR, also known ICR1, has been a matter of intensive
focus owing to its known association with pathogenesis of some congenital imprinting …

… of the H19 ICR in H19 and Igf2 regulation. The mechanism involved by the H19 ICR in the
repression of the maternal Igf2 … To test the possibility that the H19 ICR operates as a position…

… 39 Figure 11 Model of imprinting at the H19–IGF2 locus. DNA methylation at ICR1 on the
paternal allele prevents CTCF binds, resulting in the expression of IGF2 and IGF2 silence. In …

… ICR1, which is an ICR of the IGF2/H19 imprinted domain, to protect it from de novo methylation
[… Primary epimutations are aberrant methylations of ICRs without genetic alterations, and …

… (B, C & D) Methylation levels of individual CpG sites from the ICR1 (B), ICR2 (C) and … that
it mediates the expression changes we observed for Igf2 and H19. In addition, Plagl1 DMR …

… (ICR1), and one with maternally-derived DNA methylation (… this led to acquisition of aberrant
methylation on the maternal allele… of DNA methylation at the ICR of the Igf2–H19 locus. This …

… the paternally methylated gene loci Dlk1-Dio3, H19-Igf2 and … Interestingly, DNA methylation
of H19 and Rasgrf1 ICRs was … to address whether aberrant methylation patterns are tissue-…

… are not always accompanied by hypermethylation, and the aberrant methylation patterns are
not … or mutated in the maternal H19/Igf2 ICR, the mutant ICR acquired methylation and H19/…

… The imprinted genes H19, IGF2 and SNRPN were selected for analysis. The expression … of
H19 methylation (eight CpG sites), IGF2 methylation (five CpG sites) and SNRPN methylation (…

… methylation losses at the ICRs of the Igf2-H19 and Peg3 imprinted domains [36,51]. At the
ICR of the human IGF2-H19 domain, the methylated-… sites led to aberrant methylation at the …