Transcriptional repression: the long and the short of it

AJ Courey, S Jia - Genes & development, 2001 - genesdev.cshlp.org
… to mediate repression by a variety of DNA-binding repressor … Groucho recruitment and
transcriptional repression. At least … dependent transcription factor Ume6 located a short distance

MeCP2 driven transcriptional repression in vitro: selectivity for methylated DNA, action at a distance and contacts with the basal transcription machinery

NK Kaludov, AP Wolffe - Nucleic acids research, 2000 - academic.oup.com
… We find that the transcriptional repression established by both MeCP2 and the Gal4–TRD …
of DNA-bound transcriptional repressor that may stabilize a state of repression even in the …

Mechanisms of transcriptional repression

F Rojo - Current opinion in microbiology, 2001 - Elsevier
… This will be followed by examples in which the repressor does not impede RNAP binding
to … of transcription repression can be best understood when considering that transcription

Transcriptional repression in eukaryotes: repressors and repression mechanisms

K Gaston, PS Jayaraman - Cellular and Molecular Life Sciences CMLS, 2003 - Springer
… Many transcriptional repressor proteins interact either directly … mechanisms by which
transcriptional repression is achieved … proteins allow the repression of promoters in a distance- …

Nongenic transcription, gene regulation and action at a distance

PR Cook - Journal of Cell Science, 2003 - journals.biologists.com
… motifs acting at a distance are transcription units, and that … I suggest that the act of transcription
of the regulatory motifs … a repressor (or activator) binds close to the transcription start …

Transcriptional repression in the Drosophila embryo

S Gray, H Cai, S Barolo… - … Transactions of the …, 1995 - royalsocietypublishing.org
Transcriptional repression is essential for the conversion of crude maternal gradients into
sharp … a short-range ‘quenching’ mechanism, whereby a repressor works over short distances

Repression oflacPromoter as a Function of Distance, Phase and Quality of an AuxiliarylacOperator

J Müller, S Oehler, B Müller-Hill - Journal of molecular biology, 1996 - Elsevier
… the local Lac repressor concentration at O 1 is crucial for tight repression. Maximal repression,
attributed … Other repression maxima occurred at operator distances of 92.5 and 115.5 bp, …

Action at a distance: epigenetic silencing of large chromosomal regions in carcinogenesis

SJ Clark - Human molecular genetics, 2007 - academic.oup.com
… Participation of such species in triggering transcriptional repression through chromatin
modification is currently being defined in yeast and plant systems ( 103–106 ). Interestingly, non-…

Active repression mechanisms of eukaryotic transcription repressors

W Hanna-Rose, U Hansen - Trends in Genetics, 1996 - cell.com
… activiw High charge is a common feature among other repression motifs (Table 1). In yeast,
a selection for ix)tent transcriptional repression activity from random sequences yielded a …

Deciphering a transcriptional regulatory code: modeling short‐range repression in the Drosophila embryo

WD Fakhouri, A Ay, R Sayal, J Dresch… - Molecular systems …, 2010 - embopress.org
… We allow for change in repression with distance, but make no a priori assumptions about …
consider scaling factors for each transcription factor, not just for the repressor, and binding sites …