Dynamics of DNA methylation in aging and Alzheimer's disease

HA Irier, P Jin - DNA and cell biology, 2012 - liebertpub.com
DNA methylation in neurodegenerative diseases, with a special focus on DNA methylation
dynamics … of neurodegeneration and its potential role in aging and Alzheimer's disease (AD). …

DNA methylation variability in Alzheimer's disease

Z Huo, Y Zhu, L Yu, J Yang, P De Jager, DA Bennett… - Neurobiology of …, 2019 - Elsevier
DNA methylation plays a critical role in brain aging and Alzheimer's disease (AD). While …
largely focused on testing mean DNA methylation, DNA methylation instability (quantified by …

DNA methylation in the pathology of Alzheimer's disease: from gene to cognition

CH Poon, LSR Tse, LW Lim - Annals of the New York Academy …, 2020 - Wiley Online Library
… Among epigenetic modifications, DNA methylation requires … of DNA methylation, the effects
of aberrant methylation on gene … , as well as memory epigenetics in Alzheimer's disease. …

Epigenetics in Alzheimer's disease: perspective of DNA methylation

TJ Qazi, Z Quan, A Mir, H Qing - Molecular Neurobiology, 2018 - Springer
… (FAD), and autosomal dominant Alzheimer’s disease (ADAD). Down to the minutest of …
methylation patterns like mitochondrial DNA methylation and ribosomal DNA (rDNA) methylation. …

[HTML][HTML] Association of peripheral blood DNA methylation level with Alzheimer's disease progression

…, Alzheimer's Disease Neuroimaging Initiative (ADNI) - Clinical …, 2021 - Springer
… between DNA methylation at cytosine-… DNA methylation profiles measured using Infinium®
MethylationEPIC BeadChip and AD progression in participants from the Alzheimer’s Disease

[HTML][HTML] Dynamic regulation of DNA methylation and brain functions

J Xie, L Xie, H Wei, XJ Li, L Lin - Biology, 2023 - mdpi.com
DNA methylation is involved in biological processes including neurogenesis, aging, and the
… A comprehensive understanding of dynamic DNA methylation changes during development …

[HTML][HTML] A meta-analysis of brain DNA methylation across sex, age, and Alzheimer's disease points for accelerated epigenetic aging in neurodegeneration

C Pellegrini, C Pirazzini, C Sala, L Sambati… - Frontiers in aging …, 2021 - frontiersin.org
Alzheimer's disease (AD) is characterized by specific alterations of brain DNA methylation
(… We found that the proportion of sex-dependent probes whose methylation is modified also …

Mathematical models of DNA methylation dynamics: Implications for health and ageing

L Zagkos, M Mc Auley, J Roberts… - Journal of theoretical …, 2019 - Elsevier
… In order to explore the mechanics of DNA methylation further, we compare all x i rankings
to identify a correlation between them. Interestingly, comparing x 1 rankings with x 3 rankings …

Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease

SA Semick, RA Bharadwaj, L Collado-Torres… - Acta …, 2019 - Springer
… state associated with AD, we surveyed 420,852 DNA methylation (DNAm) sites from neurotypical
… We identified 858 sites with robust differential methylation collectively annotated to 772 …

Circadian alterations during early stages of Alzheimer's disease are associated with aberrant cycles of DNA methylation in BMAL1

P Cronin, MJ McCarthy, ASP Lim, DP Salmon… - Alzheimer's & …, 2017 - Elsevier
… clock, and changes in DNA methylation have been reported in … We hypothesized that aberrant
DNA methylation may affect … Our results indicate that cycles of DNA methylation contribute …