Tranexamic acid: a review of its use in the treatment of hyperfibrinolysis

PL McCormack - Drugs, 2012 - Springer
… tolerability of tranexamic acid in conditions amenable to antifibrinolytic therapy and briefly
… In large, randomized controlled trials, tranexamic acid generally significantly reduced …

Tranexamic acid: beyond antifibrinolysis

I Prudovsky, D Kacer, VV Zucco, M Palmeri… - …, 2022 - Wiley Online Library
… outcomes of the popular antifibrinolytic drug tranexamic acid (TXA) … Antifibrinolytic agents
are widely used in the management of … Among antifibrinolytic medications are the small protein …

Antifibrinolytic therapy with tranexamic acid in pregnancy and postpartum

P Peitsidis, RA Kadir - Expert opinion on pharmacotherapy, 2011 - Taylor & Francis
… In conclusion, tranexamic acid seems to be an effective treatment for … antifibrinolytic trial),
has now been established to determine the effect of early administration of tranexamic acid on …

Studies on the mechanism of the antifibrinolytic action of tranexamic acid

M Hoylaerts, HR Lijnen, D Collen - Biochimica et Biophysica Acta (BBA) …, 1981 - Elsevier
… Human plasminogen contains structures, called lysine-binding sites, which are of importance
not only for its interaction with antifibrinolytic amino acids such as tranexamic acid but also …

Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient

EE Moore, HB Moore, E Gonzalez, A Sauaia… - …, 2016 - Wiley Online Library
… experimental work suggest antifibrinolytic therapy should be … asm for routine delivery of
tranexamic acid (TXA) to severely … selective use of an antifibrinolytic in mature trauma systems. …

Tranexamic acid for treatment and prophylaxis of bleeding and hyperfibrinolysis

I Pabinger, D Fries, H Schöchl, W Streif… - Wiener klinische …, 2017 - Springer
Antifibrinolytics, such as tranexamic acid (TXA) are used for prophylaxis and … activation
tranexamic acid (TXA) and/or ε‑aminocapronic acid (ΕΑΧΑ) have been used in the treatment of HF…

Antifibrinolytic use in the perioperative setting: aminocaproic acid and tranexamic acid

J Golembiewski - Journal of PeriAnesthesia Nursing, 2015 - jopan.org
… 7 Antifibrinolytic drugs are often used as part of the blood conservation strategy during … 8
Tranexamic acid (TXA) and ε-aminocaproic acid (EACA) act by reversibly blocking the lysine …

[PDF][PDF] Tranexamic acid: a clinical review

W Ng, A Jerath, M Wąsowicz - Anestezjologia Intensywna Terapia, 2015 - termedia.pl
… TXA as an antifibrinolytic treatment applied in a perioperative setting has strong pharmacological
and clinical grounds. Although there are other situations in which the use of TXA is …

Effect of local antifibrinolytic treatment with tranexamic acid in hemophiliacs undergoing oral surgery

S Sindet-Pedersen, S Stenbjerg - Journal of oral and maxillofacial surgery, 1986 - Elsevier
… The finding in the present study that local antifibrinolytic treatment significantly reduced the
incidence of postoperative bleeding supports the view that fibrinolysis in the oral activity is an …

[PDF][PDF] Tranexamic acid

C Earnshaw, M Poole - Anaesth Tut Week, 2019 - anestesiaentrerios.org.ar
… Exposure to the extracorporeal circuit activates the fibrinolytic system and causes platelet
dysfunction, thus in addition to its’ antifibrinolytic activity tranexamic acid helps preserve …