Recognition of methylated DNA through methyl-CpG binding domain proteins
… , DNA methylation attracts proteins that bind to the methyl-… mCpG steps in DNA, known as
methyl-CpG binding domain (MBD… transcription from non-methylated CpG promoters ( 16–19 ). …
methyl-CpG binding domain (MBD… transcription from non-methylated CpG promoters ( 16–19 ). …
The methyl-CpG binding domain and the evolving role of DNA methylation in animals
B Hendrich, S Tweedie - TRENDS in Genetics, 2003 - cell.com
… In both fish genomes, one gene encodes an MBD3 with an intact MBD that, based upon
sequence conservation, we predict to bind methylated DNA, and the other encodes a version of …
sequence conservation, we predict to bind methylated DNA, and the other encodes a version of …
Direct DNA methylation profiling using methyl binding domain proteins
Y Yu, S Blair, D Gillespie, R Jensen, D Myszka… - Analytical …, 2010 - ACS Publications
… For testing the binding of MBD proteins with methylated DNA, we chose CpG-rich target
oligonucleotide sequences from the O6-methylguanine DNA methyltransferase (MGMT) gene …
oligonucleotide sequences from the O6-methylguanine DNA methyltransferase (MGMT) gene …
[HTML][HTML] Solution structure of the methyl-CpG binding domain of human MBD1 in complex with methylated DNA
… of DNA methylation are often mediated by protein factors containing conserved methyl-CpG
binding domains (… -dependent transcriptional regulator MBD1 bound to methylated DNA. …
binding domains (… -dependent transcriptional regulator MBD1 bound to methylated DNA. …
Methyl-CpG-binding domain proteins: readers of the epigenome
… of their DNA binding domains and other catalytic or protein–protein association domains. All
… two CxxC domains preferentially bind methylated DNA, while the presence of the third CxxC …
… two CxxC domains preferentially bind methylated DNA, while the presence of the third CxxC …
[HTML][HTML] The SRA methyl-cytosine-binding domain links DNA and histone methylation
LM Johnson, M Bostick, X Zhang, E Kraft, I Henderson… - Current Biology, 2007 - cell.com
… the SRA domain of KYP binds directly to methylated DNA, and SRA domains with missense
mutations found in loss-of-function kyp mutants have reduced binding to methylated DNA in …
mutations found in loss-of-function kyp mutants have reduced binding to methylated DNA in …
Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains
HF Jørgensen, I Ben-Porath, AP Bird - Molecular and cellular …, 2004 - Taylor & Francis
… by the methyl-CpG binding domain (MBD; … domain has the ability to bind methylated DNA
(Citation17). MBD1 is a member of the subfamily of MBD proteins that do bind methylated CpG, …
(Citation17). MBD1 is a member of the subfamily of MBD proteins that do bind methylated CpG, …
Methylated DNA-binding domain 1 and methylpurine–DNA glycosylase link transcriptional repression and DNA repair in chromatin
S Watanabe, T Ichimura, N Fujita… - Proceedings of the …, 2003 - National Acad Sciences
… transcriptional repressor methylated DNA-binding domain 1 (MBD1) interacts with
methylpurine–DNA glycosylase (MPG), which excises damaged bases from substrate DNA. MPG …
methylpurine–DNA glycosylase (MPG), which excises damaged bases from substrate DNA. MPG …
Towards an understanding of DNA recognition by the methyl-CpG binding domain 1
C Rauch, M Trieb, FR Wibowo… - Journal of …, 2005 - Taylor & Francis
… DNA. The methylation signal is interpreted by proteins containing a methyl-CpG binding domain
… Based on the NMR structure of MBD1 complexed with methylated DNA we analysed the …
… Based on the NMR structure of MBD1 complexed with methylated DNA we analysed the …
Activation of mammalian DNA methyltransferase by cleavage of a Zn binding regulatory domain.
TH Bestor - The EMBO journal, 1992 - embopress.org
… DNA binding region near the C-terminus (Klimasauskas et al., 1991)] are likely to be very
near the CpG site during methyl transfer, the results of this study indicate that discrimination of …
near the CpG site during methyl transfer, the results of this study indicate that discrimination of …
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