… , a Rett syndrome mutation that abolishes binding to methylated DNA, leads to only a slight
… modes of binding to junction and methylated DNA. Binding to unmethylated DNA junctions is …

… The most comprehensive approach to study genome-wide DNA … We have found that
methyl-binding domain (MBD) enrichment … the DNA and then aim to extract only the methylated …

… DNA methylation is interpreted by a family of methyl-CpG binding domain (MBD) proteins
that … Given their common DNA binding domains, different MBD proteins might be expected to …

… DNA-binding protein of known structure. Our finding that the PWWP domain alone binds DNA
suggests that PWWP domains … DNMT1 and MBD1 (a methyl-CpG binding protein) but not …

… capable of binding to DNA and chromatin, but that the binding specificity is significantly
impaired, suggesting that interactions with methylated DNA are necessary for binding specificity. …

… Recent structural determinations of the DNA binding domain of two MBD family members,
MeCP2 and MBD1, provide a framework to model the interactions of this family with …

… with DNA sequence (29), and has not been characterized with methylated DNA, we measured
the binding of methylated … as the minimal ETS domain (Ets-1ΔN331) and the PU.1 ETS …

… DNA binding proteins. In order to probe the mechanism of selective interaction of the
methyl-binding protein with methylated DNA… binding of these oligonucleotides to the …

… diastereotopic methyl groups of the 14 valyl and leucyl residues in the DNA-binding domain
… and 13C assignments of the 28 methyl groups of Val and Leu in the DNA-binding domain 1-…

… Because MBD2 has a methyl-CpG binding domain, we tested to what extent MBD2
binding to DNA is dependent on methylation. To this end, we performed a methylated DNA …