Repression of genes by DNA methylation depends on CpG density and promoter strength: evidence for involvement of a methyl‐CpG binding protein.
J Boyes, A Bird - The EMBO journal, 1992 - embopress.org
… CpG density of the genes used in this study. The transcribed regions of the three genes
are pictured below the title of each gene; the open boxes represent exons and the thin lines …
are pictured below the title of each gene; the open boxes represent exons and the thin lines …
CpG islands influence chromatin structure via the CpG-binding protein Cfp1
JP Thomson, PJ Skene, J Selfridge, T Clouaire, J Guy… - Nature, 2010 - nature.com
… for proteins that are common to all CGIs, here we show high enrichment for Cfp1, which
selectively binds to non-methylated CpGs … , as they indicate that CpG density per se can directly …
selectively binds to non-methylated CpGs … , as they indicate that CpG density per se can directly …
Methyl‐CpG‐binding proteins: Targeting specific gene repression
E Ballestar, AP Wolffe - European journal of biochemistry, 2001 - Wiley Online Library
… with regard to the density of methyl-CpGs may account for … of CpG seem to have different
affinities for MBD proteins (our … sequence around a CpG influences binding of an MBD protein. It …
affinities for MBD proteins (our … sequence around a CpG influences binding of an MBD protein. It …
Detection method for methylation density on microarray using methyl-CpG-binding domain protein
J Luo, W Zheng, Y Wang, Z Wu, Y Bai, Z Lu - Analytical biochemistry, 2009 - Elsevier
… A method for determining methylation density of target CpG islands has been … methyl-CpG-binding
protein labeled with Cy5 fluorescence was used to identify symmetrical methyl-CpG …
protein labeled with Cy5 fluorescence was used to identify symmetrical methyl-CpG …
Gene silencing by methyl‐CpG‐binding proteins
… We have studied two proteins that bind to methylated DNA, methyl-CpG-binding protein 1
(… Boyes J, Bird A 1992 Repression of genes by DNA methylation depends on CpG density …
(… Boyes J, Bird A 1992 Repression of genes by DNA methylation depends on CpG density …
Mechanism of transcriptional regulation by methyl-CpG binding protein MBD1
N Fujita, N Shimotake, I Ohki, T Chiba… - … and cellular biology, 2000 - Am Soc Microbiol
… Based on these findings we have concluded that MBD1 acts as a transcriptional regulator
depending on the density of methyl-CpG pairs through the cooperation of MBD, CXXC, and …
depending on the density of methyl-CpG pairs through the cooperation of MBD, CXXC, and …
Methyl-CpG-binding protein MBD2 plays a key role in maintenance and spread of DNA methylation at CpG islands and shores in cancer
… CpG sites. We showed that the methyl-CpG-binding protein MBD2 preferentially binds to the
‘… Methylated CpG density was calculated as the number of CpG sites with methylation above …
‘… Methylated CpG density was calculated as the number of CpG sites with methylation above …
Methyl CpG‐binding proteins and transcriptional repression
PA Wade - Bioessays, 2001 - Wiley Online Library
… methylation density, of full-length MeCP2 from any species. … bind methylated DNA, however,
suggests that the ancestral form of this protein was a bona fide methyl CpG-binding protein, …
suggests that the ancestral form of this protein was a bona fide methyl CpG-binding protein, …
CpG binding protein (CFP1) occupies open chromatin regions of active genes, including enhancers and non-CpG islands
LN van de Lagemaat, M Flenley, MD Lynch… - Epigenetics & …, 2018 - Springer
… genomic features found that CpG density, H3K4me3 intensity … approximately 48% of CFP1
binding in open chromatin. This … : (1) binding of its ZF-CxxC domain to CpG dinucleotides; (2) …
binding in open chromatin. This … : (1) binding of its ZF-CxxC domain to CpG dinucleotides; (2) …
Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function
X Zhao, T Ueba, BR Christie… - Proceedings of the …, 2003 - National Acad Sciences
… density. Because MBD1 is expressed at a high level in adult hippocampus, we analyzed the
… density of the granule cell layer of the DG. Using stereology, we found that the cell density in …
… density of the granule cell layer of the DG. Using stereology, we found that the cell density in …
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