Causes and consequences of DNA hypomethylation in human cancer

MJ Hoffmann, WA Schulz - Biochemistry and cell biology, 2005 - cdnsciencepub.com
… Third, DNA hypomethylation may … DNA replication and activity of DNA methyltransferases.
Finally, because of their relation to tumor progression and metastasis, DNA hypomethylation

DNA hypomethylation in the origin and pathogenesis of human diseases

IP Pogribny, FA Beland - Cellular and Molecular Life Sciences, 2009 - Springer
… role and place of the disease-linked DNA hypomethylation [9]. This review presents evidence
suggesting the involvement of DNA hypomethylation in the pathogenesis of several major …

DNA hypomethylation and human diseases

AS Wilson, BE Power, PL Molloy - … et Biophysica Acta (BBA)-Reviews on …, 2007 - Elsevier
… recent reviews in DNA hypomethylation and … DNA in disease, predominantly in terms of the
affected repeat sequences and transposable elements, by describing global hypomethylation

[HTML][HTML] DNA hypomethylation affects cancer-related biological functions and genes relevant in neuroblastoma pathogenesis

G Mayol, JI Martín-Subero, J Ríos, A Queiros, M Kulis… - PloS one, 2012 - journals.plos.org
… and biological subtypes of NB. We observed that gene-specific loss of DNA methylation is
… Remarkably, such hypomethylation affected cancer-related biological functions and genes …

DNA hypomethylation and ovarian cancer biology

M Widschwendter, G Jiang, C Woods, HM Müller… - Cancer research, 2004 - AACR
… We conclude that satellite DNA hypomethylation is an important issue in ovarian carcinogenesis
as demonstrated by: (a) an increase from non-neoplastic tissue toward ovarian cancer; (…

DNA hypomethylation in cancer cells

M Ehrlich - Epigenomics, 2009 - Future Medicine
DNA hypomethylation was the initial epigenetic … hypomethylation of DNA in cancer was
most closely associated with repeated DNA elements, cancer linked-DNA hypomethylation

DNA hypomethylation and hemimethylation in cancer

M Ehrlich, M Lacey - Epigenetic alterations in oncogenesis, 2012 - Springer
DNA hypomethylation in human cancers by high performance liquid chromatography analysis
of enzymatic DNA digests [1], we fractionated one adenocarcinoma DNA into … cancer DNA

[HTML][HTML] Global DNA hypomethylation in cancer: review of validated methods and clinical significance

EG Toraño, S Petrus, AF Fernandez… - Clinical chemistry and …, 2012 - degruyter.com
… It is well-known that during carcinogenesis, a site-specific DNA hypermethylation and a
global DNA hypomethylation take place. This overall loss of DNA methylation has been …

Oncogenic roles of DNA hypomethylation through the activation of cancer-germline genes

A Van Tongelen, A Loriot, C De Smet - Cancer letters, 2017 - Elsevier
… A remarkable consequence of DNA hypomethylation in … germline-specific genes that use
DNA methylation as a primary … the concept that DNA hypomethylation promotes tumorigenesis …

DNA hypomethylation in cancer: epigenetic scars of a neoplastic journey

C De Smet, A Loriot - Epigenetics, 2010 - Taylor & Francis
hypomethylated. This review discusses our current understanding of the mechanisms that
lead to DNA hypomethylation in … into mosaic hypomethylation patterns. it is proposed that such …