Brain organoids for the study of human neurobiology at the interface of in vitro and in vivo

I Chiaradia, MA Lancaster - Nature Neuroscience, 2020 - nature.com
… Guiding further organoid methods based upon signaling pathways in vivo Brain organoids
are beginning to shift the way we study human brain development in vitro, particularly as the …

[HTML][HTML] Human neural organoids: Models for developmental neurobiology and disease

B Guy, JS Zhang, LH Duncan, RJ Johnston Jr - Developmental biology, 2021 - Elsevier
organoidhuman neural organoid systems, how they are generated, advances in 3D imaging
and bioengineering, and the impact of organoid studies on our understanding of the human

Assembling human brain organoids

SP Paşca - Science, 2019 - science.org
human neurobiology. Here, I discuss the emerging approaches to produce brain
assembloids—the next generation of brain organoids … interactions between various brain regions …

Three-dimensional modeling of human neurodegeneration: brain organoids coming of age

K Grenier, J Kao, P Diamandis - Molecular psychiatry, 2020 - nature.com
… However, animal models are poorly representative of the most complex aspects of human
cognitive neurobiology and, not surprisingly, have yielded very few major discoveries with …

Using brain organoids to study human neurodevelopment, evolution and disease

C Kyrousi, S Cappello - Wiley Interdisciplinary Reviews …, 2020 - Wiley Online Library
… or cerebral organoids, are of great … of human corticogenesis and the use of brain organoids
to study it. We will discuss the key differences between cortical development in human and …

Applications of human brain organoids to clinical problems

HI Chen, H Song, G Ming - Developmental Dynamics, 2019 - Wiley Online Library
… the human brain, including progenitor zones and rudimentary cortical layers. Brain organoids
have been valuable in investigating different aspects of developmental neurobiology and …

The promises and challenges of human brain organoids as models of neuropsychiatric disease

G Quadrato, J Brown, P Arlotta - Nature medicine, 2016 - nature.com
… The recent development of 3D brain organoids derived from human … to human pathology.
Here we discuss the advantages, limitations and future applications of human brain organoids

Modeling brain development and diseases with human cerebral organoids

Y Shi, Q Wu, X Wang - Current Opinion in Neurobiology, 2021 - Elsevier
… the human brain development and uncovering the pathology of brain diseases. In this
review, we mainly summarized the recent advances in the development of brain organoid

Brain organoids: human 3D models to investigate neuronal circuits assembly, function and dysfunction

M Tambalo, S Lodato - Brain Research, 2020 - Elsevier
brain organoid protocols and their use as a system for studying different aspects of human
brain … These efforts have drastically pushed forward the field of neurobiology with unforeseen …

Modeling neurological diseases with human brain organoids

H Wang - Frontiers in synaptic neuroscience, 2018 - frontiersin.org
… introduction of recent advancements in human brain organoid models and their application
in … the impact of human brain organoid system on our understanding of neurobiology and …