The breast tumor microenvironment: role in cancer development, progression and response to therapy

S Mittal, NJ Brown, I Holen - Expert review of molecular diagnostics, 2018 - Taylor & Francis
… genetics and the molecular pathways involved in tumor development, cancer remains the
leading cause of death. Breast cancer is the most frequently diagnosed cancer among women […

Effects of estrogen on breast cancer development: Role of estrogen receptor independent mechanisms

W Yue, JP Wang, Y Li, P Fan, G Liu… - … journal of cancer, 2010 - Wiley Online Library
tumor development without measurable uterine stimulatory effects. Taken together, our
results suggest that ER-independent actions of E 2 can influence breast tumor development in …

The role of cytokines in breast cancer development and progression

M Esquivel-Velázquez, P Ostoa-Saloma… - Journal of Interferon & …, 2015 - liebertpub.com
… MSCs are recruited to developing tumors, where they increase breast cancer cell motility,
invasion, and metastatic potential … In breast tumor development, leptin is a determinant of the …

Effect of obesity on breast cancer development

MP Cleary, ME Grossmann, A Ray - Veterinary pathology, 2010 - journals.sagepub.com
… for the development of breast cancer in postmenopausal … been implicated in the development
of mammary tumors. Because … to assess mammary tumor development. Neither obese Lep …

Breast cancer instructs dendritic cells to prime interleukin 13–secreting CD4+ T cells that facilitate tumor development

C Aspord, A Pedroza-Gonzalez, M Gallegos… - The Journal of …, 2007 - rupress.org
… independent experiments (mean tumor volume ± SEM … tumor development, we used
NOD/SCID/β2m −/− mice without CD34 + HPC grafts into which we implanted Hs578T breast cancer

The E2F transcription factors regulate tumor development and metastasis in a mouse model of metastatic breast cancer

DP Hollern, J Honeysett, RD Cardiff… - Molecular and cellular …, 2014 - Am Soc Microbiol
tumor virus (MMTV)-polyomavirus middle T oncoprotein (PyMT) mouse model of … breast
cancer. To genetically test the hypothesis that the E2Fs function to regulate tumor development

Breast stroma plays a dominant regulatory role in breast epithelial growth and differentiation: implications for tumor development and progression

MPV Shekhar, J Werdell, SJ Santner, RJ Pauley, L Tait - Cancer research, 2001 - AACR
… in breast carcinomas and in histologically normal breast … susceptibility of epithelium to
develop cancer. Aberrations in … in the development and progression of human breast cancer. …

Host microenvironment in breast cancer development: epithelial–mesenchymal transition in breast cancer development

A Vincent-Salomon, JP Thiery - Breast cancer research, 2003 - Springer
… EMT is a fundamental process in the development of most … the molecular mechanisms in the
developing embryo have been … in breast cancer progression and whether these tumor types …

Role of the tumor microenvironment in breast cancer

SD Soysal, A Tzankov, SE Muenst - Pathobiology, 2015 - karger.com
… Emerging evidence suggests that tumors consist not only of neoplastic cells but also … Indeed,
this tumor microenvironment is now recognized as a critical element for tumor development

The role of oxidative stress on breast cancer development and therapy

F Hecht, CF Pessoa, LB Gentile, D Rosenthal… - Tumor biology, 2016 - Springer
tumor development by secreting energy substrates, matrix-degrading enzymes, and
growth factors [59–62]. On the other hand, tumor cells … of metastatic breast cancer, tumor-associated …