… silencing of tumor suppressor genes by DNA methylation. The thirddevelopment has been
… to manipulate DNAmethylation levels. These studies demonstrate that DNA methylation …

… of certain tumor-suppressor genes occurs as a consequence … of genes silenced by DNA
methylation in different cancer types. … Apart from DNA methylation alterations in promoter regions …

… in human cancer cells and primary tumors are summarized in Table 1. The different classes
of genes that are silenced by DNA methylation include tumor suppressor genes, genes that …

… It is essential to our understanding of the role of DNA methylation in cancer to find out whether
the changes seen in DNA methylation patterns and MTase expression contribute to or are …

… the epigenetic silencing of genes in concert with DNA methylation in cancer cells. In normal
… interfering with the process of gene expression. DNA methylation and the acquisition of …

… These events cause critical loss of gene activity and thereby predispose to cancer. DNA
methylation can modify the gene activity without changing the gene sequence and has been …

… silencing of tumor suppressor genes that play critical … DNA methylation in cancer cells and
summarize recent advancements of techniques that facilitate genome-wide study of the cancer …

… effect of mutations of various tumor suppressor genes (TSGs) or … DNA methylation that
include hypermethylation and hypomethylation of promoter or first exon of cancer-related genes. …

… roughly correlated with a decrease in genetic expression. It is now … DNA methylation and
gene expression is specific for when methylation occurs at the promoter regions of the gene. …

… Whereas the underlying causes of cancer remains largely elusive, it has also become clear
… developing cancer [23,24,25]. Outside cancer, environmental influences on DNA methylation …