Plasma tranexamic acid concentrations during cardiopulmonary bypass

BK Fiechtner, GA Nuttall, ME Johnson… - Anesthesia & …, 2001 - journals.lww.com
… measured plasma tranexamic acid concentrations in 21 patients receiving tranexamic acid
prophylaxis according to our standard protocol for primary cardiac surgery with CPB. Our goal …

Pharmacokinetics of tranexamic acid during cardiopulmonary bypass

NP Dowd, JM Karski, DC Cheng, JA Carroll… - The Journal of the …, 2002 - pubs.asahq.org
Tranexamic acid (TA) reduces blood loss and blood transfusion during heart surgery with
cardiopulmonary bypass (CPB). TA dosing has been empiric because only limited …

High-dose tranexamic acid is an independent predictor of early seizure after cardiopulmonary bypass

D Kalavrouziotis, P Voisine, S Mohammadi… - The Annals of thoracic …, 2012 - Elsevier
… early seizure after cardiopulmonary bypass (CPB) were examined. The role of tranexamic
acid in … Current guidelines make a class I recommendation for tranexamic acid use as a blood-…

Comparison of two doses of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass

S Sigaut, B Tremey, A Ouattara, R Couturier… - …, 2014 - pubs.asahq.org
… complications of cardiac surgery is excessive … by cardiopulmonary bypass (CPB) during
and after cardiac surgery. Therefore, antifibrinolytic agents are used during cardiac surgery with …

[HTML][HTML] Prevention of bleeding after cardiopulmonary bypass with high-dose tranexamic acid: double-blind, randomized clinical trial

JM Karski, SJ Teasdale, P Norman, J Carroll… - The Journal of thoracic …, 1995 - Elsevier
cardiopulmonary bypass. One hundred fifty patients scheduled to undergo cardiac operations
with cardiopulmonary bypass were … The first group received 10 gm of tranexamic acid

Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass

V Sharma, J Fan, A Jerath, KS Pang, B Bojko… - …, 2012 - Wiley Online Library
… of high-dose tranexamic acid for 24 h after administration of the drug in patients undergoing
cardiac surgery with cardiopulmonary bypass. High-dose tranexamic acid involved a bolus …

Comparison of the effects of aprotinin and tranexamic acid on blood loss and related variables after cardiopulmonary bypass

B Blauhut, W Harringer, P Bettelheim, JE Doran… - The Journal of thoracic …, 1994 - Elsevier
… undergoing cardiopulmonary bypass for … of tranexamic acid (total dose 20 mg/kg body
weight, n =15), and nonmedicated controls (n =14) during 24 hours after cardiopulmonary bypass. …

Prophylactic tranexamic acid in elective, primary coronary artery bypass surgery using cardiopulmonary bypass

JJ Andreasen, C Nielsen - European journal of cardio-thoracic …, 2004 - academic.oup.com
… artery bypass surgery (CABG) using cardiopulmonary bypass (… Perioperative use of tranexamic
acid (TA), a synthetic … patients receiving blood transfusions in cardiac surgery. In addition, …

Tranexamic acid reduces bleeding after cardiopulmonary bypass when compared to epsilon aminocaproic acid and placebo

ML Pinosky, DJ Kennedy, RL Fishman… - … of cardiac surgery, 1997 - Wiley Online Library
… Group TA (N = 20 ) received tranexamic acid as an intravenous loading dose of 15 mg/kg,
followed by a continuous infusion of 1 mg/kg per hour for 6 hours. The control group (N = 19) …

Population pharmacokinetics of tranexamic acid in adults undergoing cardiac surgery with cardiopulmonary bypass

S Grassin-Delyle, B Tremey, E Abe… - British journal of …, 2013 - academic.oup.com
tranexamic acid (TA) has grown since the widespread removal of aprotinin, but its dosing
during cardiac surgery … in adult cardiac surgery patients during cardiopulmonary bypass (CPB). …