Epigenetics, DNA methylation, and chromatin modifying drugs
M Szyf - Annual review of pharmacology and toxicology, 2009 - annualreviews.org
… In summary, chromatin modification and DNA methylation and demethylation machineries …
in DNA methylation or histone modification require targeting of histone and DNA modification …
in DNA methylation or histone modification require targeting of histone and DNA modification …
[PDF][PDF] Interplay between DNA methylation, histone modification and chromatin remodeling in stem cells and during development.
… and constitutes the DNA methylation profile genome-wide. Since the DNA methylation profile
is specific … The formation of DNA methylation profiles is the basis for cell differentiation and …
is specific … The formation of DNA methylation profiles is the basis for cell differentiation and …
DNA methylation, chromatin inheritance, and cancer
… Understanding the molecular determinants of both normal and abnormal patterns of chromatin
formation and DNA methylation thus holds great promise for our understanding of cancer …
formation and DNA methylation thus holds great promise for our understanding of cancer …
The role of DNA methylation in setting up chromatin structure during development
… Our studies thus suggest that the average residence time of H1 on chromatin is not substantially
affected by DNA methylation itself or its derivative histone modification pattern. Rather, it …
affected by DNA methylation itself or its derivative histone modification pattern. Rather, it …
Chromatin remodeling, histone modifications, and DNA methylation—how does it all fit together?
TM Geiman, KD Robertson - Journal of cellular biochemistry, 2002 - Wiley Online Library
… modifications of the mammalian genome. A model will also be put forth to account for how
chromatin modifications lead to genomic DNA methylation … DNA methylation is an epigenetic …
chromatin modifications lead to genomic DNA methylation … DNA methylation is an epigenetic …
Epigenetics: interaction of DNA methylation and chromatin
M Nakao - Gene, 2001 - Elsevier
… that epigenetics is achieved by DNA methylation and chromatin. Wolffe further placed …
DNA methyltransferases, methyl-CpG binding proteins, histone-modifying enzymes, chromatin …
DNA methyltransferases, methyl-CpG binding proteins, histone-modifying enzymes, chromatin …
DNA methylation and chromatin–unraveling the tangled web
KD Robertson - Oncogene, 2002 - nature.com
… between DNA methylation and chromatin … chromatin states may dictate genome-wide DNA
methylation patterning. The mammalian DNA methylation machinery – properties of the DNA …
methylation patterning. The mammalian DNA methylation machinery – properties of the DNA …
DNA methylation affects the formation of active chromatin
I Keshet, J Lieman-Hurwitz, H Cedar - Cell, 1986 - cell.com
… is equivalent to that obtained with the Ml3 constructs used in this study, and one would expect
this level of DNA modification to have a profound effect on chromatin structure in vivo. In …
this level of DNA modification to have a profound effect on chromatin structure in vivo. In …
Linking DNA methylation and histone modification: patterns and paradigms
H Cedar, Y Bergman - Nature Reviews Genetics, 2009 - nature.com
… closed chromatin structure owing to de novo methylation that … the maintenance of DNA
methylation and chromatin structure … in chromatin structure and removal of DNA methylation 55 . …
methylation and chromatin structure … in chromatin structure and removal of DNA methylation 55 . …
DNA methylation and chromatin modification
HH Ng, B Adrian - Current opinion in genetics & development, 1999 - Elsevier
… relationship between DNA methylation and chromatin structure. … by DNA methylation. Taken
together, the data strongly suggest that DNA methylation can pattern chromatin modification. …
together, the data strongly suggest that DNA methylation can pattern chromatin modification. …
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