… In conclusion, our findings suggest that dysregulated DNA methylation and active DNA
demethylation in CLL B cells have a critical impact on disease progression and their association …

… Despite the high frequency and importance of epigenetic alterations, the contribution of
DNA methylation patterns to heterogeneity and evolution of tumor cell populations, and their …

… and post-relapse samples of 34 CLL patients treated with … that DNA methylation profiles
are modulated during CLL … Moreover, we evaluated the DNA methylation alterations occuring …

… data measuring DNA methylation, we identified the epigenetic alterations (more specifically,
DNA methylation) and genetic mutations along non-coding genomic regions CLL, and …

… modifications occurring during lineage development 7 . The establishment of normal DNA
methylation … Diseased tissues regularly exhibit degradation of DNA methylation patterns 9 . In …

… Since this methylation alteration was detected analyzing whole blood samples and a
differential cell type content has an effect on DNA methylation profile, we investigated cell type …

… Recent epigenetic studies have found that M-CLL maintains the DNA methylation signature
… homotypic B-cell receptor interactions shape the outcome of chronic lymphocytic leukaemia …

… , we performed a genome-wide methylation profile of patients with CLL using methylated
CpG … specific methylation alterations with potential functional and clinical relevance in CLL. …

… focused on +12 U-CLL revealed the presence of chromatin activation. As transcription factor
(TF) binding has been described to be related to DNA methylation and chromatin activity, 12 …

… CpG island methylation is an epigenetic alteration that … island methylation in chronic
lymphocytic leukemia (CLL). To … , at least in part, by DNA methylation, and that expression levels …