[HTML][HTML] CD18 (ITGB2) expression in chronic lymphocytic leukaemia is regulated by DNA methylation-dependent and-independent mechanisms

E Hutterer, D Asslaber, C Caldana… - British journal of …, 2015 - ncbi.nlm.nih.gov
Chronic lymphocytic leukaemia (CLL) cells strongly depend on the lymphoid microenvironment,
where they transiently localize to receive supportive signals by accessory cells (Burger …

Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)

A Palamarchuk, PS Yan, N Zanesi… - Proceedings of the …, 2012 - National Acad Sciences
… showed a decrease in DNA methylation compared with CLL samples with low … leukemia
and myelodysplastic syndrome, our results suggest that inhibition of de novo DNA methylation

DNA methylation of tumor-suppressor miRNA genes in chronic lymphocytic leukemia

LQ Wang, CS Chim - Epigenomics, 2015 - Taylor & Francis
… Therefore, the role of DNA methylation was explored in Eu-TCL1 mice by performing a
genome-wide DNA methylation study by Restriction Landmark Genomic Study in B cells from …

ZAP-70 intron1 DNA methylation status: determination by pyrosequencing in B chronic lymphocytic leukemia

SP Chantepie, D Vaur, C Grunau, V Salaün, M Briand… - Leukemia research, 2010 - Elsevier
DNA methylation analysis of CLL samples by pyrosequencing can be done without purification
of B cells. Immunophenotyping of the sample determines the relative amount of T cells, …

Time to relapse in chronic lymphocytic leukemia and DNA-methylation-based biological age

DR Nannini, R Cortese, P Egwom, S Palaniyandi… - Clinical …, 2023 - Springer
… is associated with time to CLL relapse. Our results provide novel insight into the association
between age-related DNA methylation changes and CLL relapse and may serve has …

Epigenetic deregulation in chronic lymphocytic leukemia: Clinical and biological impact

L Mansouri, JA Wierzbinska, C Plass… - Seminars in cancer …, 2018 - Elsevier
… More recently, DNA methylation profiles in CLL analyzed in relation to differentiating normal
… More recently, genome-wide methylation analysis of CLL in the context of normal B cell sub-…

Epigenetic and genetic alterations and their influence on gene regulation in chronic lymphocytic leukemia

D Huang, I Ovcharenko - BMC genomics, 2017 - Springer
… our analysis with the genome-wide DNA methylation profiles previously established by
applying reduced representation bisulfite sequencing (RRBS) to CD19+ B-cells from 32 CLL

A B-cell epigenetic signature defines three biologic subgroups of chronic lymphocytic leukemia with clinical impact

AC Queirós, N Villamor, G Clot, A Martinez-Trillos… - Leukemia, 2015 - nature.com
chronic lymphocytic leukemia (CLL) destined to progress would greatly facilitate their clinical
management. Recently, whole-genome DNA methylation analyses … that DNA methylation

[HTML][HTML] Krüppel-like factor 4 (KLF4) inactivation in chronic lymphocytic leukemia correlates with promoter DNA-methylation and can be reversed by inhibition of …

K Filarsky, A Garding, N Becker, C Wolf… - …, 2016 - ncbi.nlm.nih.gov
DNA-methylation analyses of CLL as the 450K arrays used previously do not include this
region… Analysis of KLF4 promoter DNA-methylation in randomly selected, representative CLL

ANGPT2 promoter methylation is strongly associated with gene expression and prognosis in chronic lymphocytic leukemia

S Martinelli, M Kanduri, R Maffei, S Fiorcari… - Epigenetics, 2013 - Taylor & Francis
… status between IGHV mutated and unmutated CLL patients in our previous methylation study
an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL). Proc …