… in patients with CLL. The clarification of the role of p16 gene … methylation in the pathogenesis
and evolution of CLL needs further investigation. Chronic lymphocytic leukemia (CLL) …

… Chronic lymphocytic leukaemia (CLL) exhibits differences … Differential methylation analysis
between the CLL and … for data normalization and differential methylation analysis was set to …

… the MassARRAY technique for DNA methylation assessment, … -70 methylation analysis to
practical use in CLL management… To increase the applicability of ZAP-70 methylation analysis, …

… To assess the reproducibility of the methylation assay used here, we repeated 150 of the
720 non-MSP reactions. The Spearman rank order correlation coefficient between different …

… (A) Locally disordered DNA methylation is higher in CLL and cancer tissues compared with
normal tissues, including B cells (adapted from Landau et al18); (B) Adverse impact of locally …

… CLL patients and demonstrated the role of DNA methylation in … -wide DNA methylation analysis
in CD8 + T cells from CLL … and identified other differentially methylated genes with known …

… to chronic lymphocytic leukemia (CLL). To gain insight into the mechanisms underlying CLL
risk we analyze … elements marked by H3K27ac, and DNA methylation at 42 risk loci in up to …

… , particularly in chronic lymphocytic leukemia (CLL). This study focuses on a unique approach:
the immunoprecipitation-based capture of double-stranded, methylated DNA fragments …

… In this study, we investigated epigenetic alterations in this CLL mouse model at various
times before development of disease. We demonstrate that DNA methylation changes occur …

… and gene-specific aberrant DNA methylation have been observed in CLL. Aberrant
methylation has been described for genes that are specifically deregulated in CLL, such as BCL2, …