DNA methylation: TET proteins—guardians of CpG islands?
K Williams, J Christensen, K Helin - EMBO reports, 2012 - embopress.org
… is DNA methylation. In mammals, DNA methylation occurs predominantly at CpG … that
establish DNA methylation patterns by targeting unmethylated CpG sites. DNMT1 acts …
establish DNA methylation patterns by targeting unmethylated CpG sites. DNMT1 acts …
HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination
… DNA methylation might be the prime epigenetic mechanism affecting meiotic recombination.
Methylation … MI was indicative of DNA methylation, we correlated the CpG island base count …
Methylation … MI was indicative of DNA methylation, we correlated the CpG island base count …
DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease
DM Jeziorska, RJS Murray… - Proceedings of the …, 2017 - National Acad Sciences
… events lead to establishment of methylation and silencing of the transcribed CGIs. Importantly,
we finally show that transcription-mediated DNA methylation is a general mechanism …
we finally show that transcription-mediated DNA methylation is a general mechanism …
Tuning methylation-dependent silencing dynamics by synthetic modulation of CpG density
… (26) Here, to focus on the role of DNA methylation in silencing, we specifically used the
mouse gene Dnmt3b′s catalytic domain, spanning amino acids 402–872. This region omits the …
mouse gene Dnmt3b′s catalytic domain, spanning amino acids 402–872. This region omits the …
DNA methylation and DNA methyltransferases
JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
… fidelity of maintenance methylation. Rather than a general overview of DNA methylation in
… analysis of the distribution of methylated CpG dinucleotides across the multiple sequence …
… analysis of the distribution of methylated CpG dinucleotides across the multiple sequence …
Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications
… To examine the reliability of an enrichment-based method specifically for inferring weakly
methylated regions at different CpG densities, we compared MeDIP-seq to MethylC-seq (…
methylated regions at different CpG densities, we compared MeDIP-seq to MethylC-seq (…
Synthetic CpG islands reveal DNA sequence determinants of chromatin structure
E Wachter, T Quante, C Merusi, A Arczewska, F Stewart… - Elife, 2014 - elifesciences.org
… We find, however, that A + T-rich CpG-rich sequences are reproducibly DNA methylated
despite their ability to attract H3K4me3 when DNA methylation is absent. Since these …
despite their ability to attract H3K4me3 when DNA methylation is absent. Since these …
Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome
… CpG-rich promoters that are protected from DNA methylation … state can predict the DNA
methylation state of inactive CpG-rich … in protecting CpG-rich promoters from DNA methylation. …
methylation state of inactive CpG-rich … in protecting CpG-rich promoters from DNA methylation. …
The DNA methylation paradox
PA Jones - Trends in genetics, 1999 - cell.com
… Not all CpG islands and methylation sites are located in known promoters; several tissue-…
of DNA methylation is permanent gene suppression mediated through the modification of CpG …
of DNA methylation is permanent gene suppression mediated through the modification of CpG …
Discordance of DNA methylation variance between two accessible human tissues
… Specifically we compared probe-wise DNA methylation variance and how … DNA methylation
than BECs and the two tissues tended to differ most at genomic regions of low CpG density. …
than BECs and the two tissues tended to differ most at genomic regions of low CpG density. …