DNA methylation: TET proteins—guardians of CpG islands?

K Williams, J Christensen, K Helin - EMBO reports, 2012 - embopress.org
… is DNA methylation. In mammals, DNA methylation occurs predominantly at CpG … that
establish DNA methylation patterns by targeting unmethylated CpG sites. DNMT1 acts …

HapMap methylation-associated SNPs, markers of germline DNA methylation, positively correlate with regional levels of human meiotic recombination

MI Sigurdsson, AV Smith, HT Bjornsson… - Genome …, 2009 - genome.cshlp.org
DNA methylation might be the prime epigenetic mechanism affecting meiotic recombination.
Methylation … MI was indicative of DNA methylation, we correlated the CpG island base count …

DNA methylation of intragenic CpG islands depends on their transcriptional activity during differentiation and disease

DM Jeziorska, RJS Murray… - Proceedings of the …, 2017 - National Acad Sciences
… events lead to establishment of methylation and silencing of the transcribed CGIs. Importantly,
we finally show that transcription-mediated DNA methylation is a general mechanism …

Tuning methylation-dependent silencing dynamics by synthetic modulation of CpG density

Y Ma, MW Budde, J Zhu, MB Elowitz - ACS Synthetic Biology, 2023 - ACS Publications
… (26) Here, to focus on the role of DNA methylation in silencing, we specifically used the
mouse gene Dnmt3b′s catalytic domain, spanning amino acids 402–872. This region omits the …

DNA methylation and DNA methyltransferases

JR Edwards, O Yarychkivska, M Boulard… - Epigenetics & …, 2017 - Springer
… fidelity of maintenance methylation. Rather than a general overview of DNA methylation in
… analysis of the distribution of methylated CpG dinucleotides across the multiple sequence …

Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications

RA Harris, T Wang, C Coarfa, RP Nagarajan… - Nature …, 2010 - nature.com
… To examine the reliability of an enrichment-based method specifically for inferring weakly
methylated regions at different CpG densities, we compared MeDIP-seq to MethylC-seq (…

Synthetic CpG islands reveal DNA sequence determinants of chromatin structure

E Wachter, T Quante, C Merusi, A Arczewska, F Stewart… - Elife, 2014 - elifesciences.org
… We find, however, that A + T-rich CpG-rich sequences are reproducibly DNA methylated
despite their ability to attract H3K4me3 when DNA methylation is absent. Since these …

Distribution, silencing potential and evolutionary impact of promoter DNA methylation in the human genome

M Weber, I Hellmann, MB Stadler, L Ramos, S Pääbo… - Nature …, 2007 - nature.com
CpG-rich promoters that are protected from DNA methylation … state can predict the DNA
methylation state of inactive CpG-rich … in protecting CpG-rich promoters from DNA methylation. …

The DNA methylation paradox

PA Jones - Trends in genetics, 1999 - cell.com
… Not all CpG islands and methylation sites are located in known promoters; several tissue-…
of DNA methylation is permanent gene suppression mediated through the modification of CpG

Discordance of DNA methylation variance between two accessible human tissues

R Jiang, MJ Jones, E Chen, SM Neumann, HB Fraser… - Scientific reports, 2015 - nature.com
… Specifically we compared probe-wise DNA methylation variance and how … DNA methylation
than BECs and the two tissues tended to differ most at genomic regions of low CpG density. …