Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse

H Kroeger, J Jelinek, MRH Estécio, R He… - Blood, The Journal …, 2008 - ashpublications.org
… Its impact in leukemia progression is not fully understood. We … CpG islands and identified
8 genes frequently methylated in leukemia cell lines and in patients with acute myeloid

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

AD Kelly, H Kroeger, J Yamazaki, R Taby, F Neumann… - Leukemia, 2017 - nature.com
… Genetic changes are infrequent in acute myeloid leukemia (… -cured, we found higher CpG
island (CGI) promoter methylation … Aberrant CpG island methylation in acute myeloid leukemia

Selective variegated methylation of the p15 CpG island in acute myeloid leukemia

JE Dodge, AF List, BW Futscher - International journal of …, 1998 - Wiley Online Library
… The purpose of our study was to determine the methylation patterns of the p15, p16 and dCK
CpG islands in normal blood, acute myeloid leukemia (AML) and leukemia cell lines. Using …

Methylation profiling in acute myeloid leukemia

M Toyota, KJ Kopecky, MO Toyota… - Blood, The Journal …, 2001 - ashpublications.org
CpG islands has been described in acute myeloid leukemia (… of 14 promoter-associated
CpG islands was analyzed in 36 … For each of these CpG islands, the methylation density was …

Genome-wide profiling of CpG methylation identifies novel targets of aberrant hypermethylation in myeloid leukemia

C Gebhard, L Schwarzfischer, TH Pham, E Schilling… - Cancer research, 2006 - AACR
… efficiently binds native CpG-methylated DNA. In combination with CpG island microarrays, …
>100 genes with aberrantly methylated CpG islands in three myeloid leukemia cell lines. …

[HTML][HTML] Dynamic DNA methylation change in the CpG island region of p15 during human myeloid development

K Sakashita, K Koike, T Kinoshita… - The Journal of …, 2001 - Am Soc Clin Investig
… patterns of CpG island methylation in three leukemic cell lines. … Physiologic role of p15 CpG
island methylation in myeloid … in CpG island methylation of the p15 gene in normal myeloid

… Island Mapping with Pyrosequencing™ Reveals Disease-Specific Methylation Patterns of the CDKN2B Gene in Myelodysplastic Syndrome and Myeloid Leukemia

K Brakensiek, LU Wingen, F Langer, H Kreipe… - Clinical …, 2007 - academic.oup.com
… methylation status of 68 CpG sites in the CpG island of the CDKN2B … myeloid malignancies,
in a series of bone marrow samples from patients with myelodysplasia and myeloid leukemia

Analysis of histone modification around the CpG island region of the p15 gene in acute myeloblastic leukemia

M Ogawa, K Sakashita, XY Zhao, A Hayakawa… - Leukemia research, 2007 - Elsevier
… varies in primary acute leukemia, whereas the entire CpG island region of p15 in normal …
at the p15 CpG island and the inverse expression of p15 during normal myeloid development …

KG-1 and KG-1a model the p15 CpG island methylation observed in acute myeloid leukemia patients

JE Dodge, C Munson, AF List - Leukemia research, 2001 - Elsevier
… To address whether DNA methylation of the p15 CpG island was associated with gene …
human myeloid cell lines HL60 (acute myeloid leukemia), KG-1 (acute myeloid leukemia), and KG…

Concurrent DNA hypermethylation of multiple genes in acute myeloid leukemia

JR Melki, PC Vincent, SJ Clark - Cancer research, 1999 - AACR
… methylation pattern of the CpG islands associated with the … normal and 20 patients with acute
myeloid leukaemia (AML). All … deregulation of CpG island methylation in leukemia and that …