… of the promoter CpG island during the process of carcinogenesis in human HCC. In this …
of the p16 INK4a promoter CpG island is a very late event in hepatocarcinogenesis. On the …

… status of CpG islands of 9 genes, … CpG island methylation of tumor-related genes is an
early and frequent event, and accumulates step-by-step during a multistep hepatocarcinogenesis…

… The number of hypermethylated CpG island loci in human multistep hepatocarcinogenesis
The mean number of hypermethylated CpG island loci in our DNA samples were 1.30 ± 1.15, …

… HCC proceeds via a similar mechanism, a new model for human hepatocarcinogenesis can
be proposed. In this new model, normal hepatocytes do not express GSTPl, but when cells …

… methylation with transcription inactivation might play an important role in hepatocarcinogenesis,
and 5’CpG island methylation was the major mechanism of p16 gene inactivation. …

… the 7 CpG islands examined in the present article; however, further studies are needed to
confirm the molecular basis of the involvement of DNMT2 in human hepatocarcinogenesis. …

… Purpose: This study aims to determine the relationship between CpG island DNA …
along the multistep hepatocarcinogenesis. Depending on the type of CpG island locus, a …

… in human HCC cells, a series of 43 HBV-associated HCC tissue specimens were analyzed
for GSTP1 CpG island … We surveyed the CpG island hypermethylation status in CpG island …

… occur in a progressive manner during hepatocarcinogenesis. Lower levels of methylation …
frequent hypermethylation of CpG islands of the 14-3-3 σ gene in human cancer and extend …

… (CpG) sites covering 96% of known CpG islands. New samples analyzed included 6
healthy liver tissue (ie, adjacent histological healthy liver from hepatic resections due to a …