… The specificity of CRISPR/Cas9-mediated DNA cleavage requires target sequences …
CRISPR/Cas9-mediated genome editing and clinical therapeutic potential of CRISPR/Cas9 …

… the utilization of CRISPR/Cas9 in a variety of … of CRISPR/Cas9-mediated gene editing in
human cells, especially in embryos. Because ethical concerns preclude studies of gene editing …

… of the CRISPR-Cas9 genome-editing … CRISPR-Cas9 system to edit gene sequences.
We will then highlight the current systems that have been developed to deliver the CRISPR-Cas9 …

… Here we demonstrate that CRISPR/Cas9 is also effective as a gene-editing tool in human
2PN zygotes. By injection of Cas9 protein complexed with the appropriate sgRNAs and …

… Several studies recently used CRISPR/Cas9 to successfully modulate … genome editing in
the clinics. In this review, we will summarize and discuss such preclinical CRISPR/Cas9 gene …

… Cas9 function and the structural and biochemical studies that support it. We focus on the
applications of Cas9 for genome editing… many advantages that CRISPR/Cas9 technology offers. …

… repeat/Cas9 (CRISPR/Cas9)–mediated genome editing to correct the dystrophin … genetic
defect in the Dmd gene of mdx mice by CRISPR/Cas9–mediated genome editing in vivo. The …

… the CRISPR–Cas9 system. We also describe on the applications of this technology in
gene regulation and genome editing; … ; and limitations and concerns of the use of CRISPR–Cas9. …

… Gene modifications in animal models have been greatly facilitated through the application
of targeted genome editing tools. The prokaryotic CRISPR/Cas9 type II genome editing …

… Here, we review current status of CRISPR/Cas9 gene editing technology in oncological …
of CRISPR/Cas9 gene editing and introduce several new CRISPR-based gene editing modes. …