Cryptococcus neoformans capsular polysaccharides form branched and complex filamentous networks viewed by high-resolution microscopy
GRS Araujo, GN Fontes, D Leão, GM Rocha… - Journal of structural …, 2016 - Elsevier
Cryptococcus neoformans is a fungal pathogen that causes life-threatening infections in
immunocompromised individuals. Its main virulence factor is an extracellular polysaccharide
capsule whose structure, assembly and dynamics remain poorly understood. In this study,
we apply improved protocols for sample preparation and recently-developed scanning
microscopy techniques to visualize the ultrastructure of the C. neoformans capsule at high-
resolution (up to 1 nm) and improved structural preservation. Although most capsule …
immunocompromised individuals. Its main virulence factor is an extracellular polysaccharide
capsule whose structure, assembly and dynamics remain poorly understood. In this study,
we apply improved protocols for sample preparation and recently-developed scanning
microscopy techniques to visualize the ultrastructure of the C. neoformans capsule at high-
resolution (up to 1 nm) and improved structural preservation. Although most capsule …
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