… the current understanding of how the various genotypes and phenotypes observed in C. …
interplay between genetics and phenotype to understand and prevent C. neoformans disease. …

… To determine whether the sgf29 mutation in the Laboratory lineage was responsible for the
observed hypervirulence phenotype, we infected mice with H99O, the H99O sgf29∆ mutant, …

… One interesting observation is that hypervirulent switch variants, which result from phenotypic
switching, appear to exhibit a shortened replicative life span [8]. Specifically, this means …

… H99L lineage has been implicated in the switch to hypervirulence, we investigated the effect
of SGF29 deletion on the production of cell phenotype variants. To do so, we used SGF29 …

… mechanisms that have equipped Cryptococcus neoformans and Cryptococcus gattii to be …
Clinical and environmental isolates are often labeled as either hypervirulent, intermediate, …

… STM phenotypes and virulence phenotypes. Both hypovirulent and hypervirulent strains were
accurately identified by STM… P-values indicate the significance of the virulence phenotype. …

… Cryptococcus neoformans is a fungal pathogen that causes almost half a million deaths each
year. It is believed that most humans are infected with C. … Cryptococcus neoformans is the …

… neoformans is ubiquitous, but a higher rate of infection is … phenotype or there are differences
in the virulence of the fungal strains found in these niches. More recently, hypervirulent …

… The strains used in this study were Cryptococcus neoformans serotypes A and D. For
phenotypic analysis we used the sequenced serotype A laboratory strain H99α and a mutant, …

… loss of all1Δ confers the hypervirulent phenotype of the MC variant. Our data demonstrate
that two key components of an effective host response in chronic cryptococcosis are modified, …